Angiotensin-converting enzyme inhibition by Brazilian plants

被引:41
作者
Braga, Fernao C.
Serra, Carla P.
Viana, Nilton S., Jr.
Oliveira, Alaide B.
Cortes, Steyner F.
Lombardi, Julio A.
机构
[1] UMG, Fac Farm, BR-31270010 Belo Horizonte, MG, Brazil
[2] Univ Fed Ouro Preto, Lab Farmacol Expt, Escola Farm, Ouro Preto, Brazil
[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Farmacol, Belo Horizonte, MG, Brazil
[4] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bot, Belo Horizonte, MG, Brazil
关键词
angiotensin-converting enzyme inhibition; colorimetric assay; Brazilian flora;
D O I
10.1016/J.fitote.2007.02.007
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The potential antihypertensive activity of Brazilian plants was evaluated in vitro by its ability to inhibit the angiotensin-converting enzyme (ACE). Forty-four plants belonging to 30 families were investigated. Plants were selected based on their popular use as antihypertensive and/or diuretics. The following plants presented significant ACE inhibition rates: Calophyllum brasiliense, Combretum fruticosum, Leea rubra, Phoenix roebelinii and Terminalia catappa. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:353 / 358
页数:6
相关论文
共 40 条
[1]   Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins [J].
Actis-Goretta, L ;
Ottaviani, JI ;
Keen, CL ;
Fraga, CG .
FEBS LETTERS, 2003, 555 (03) :597-600
[2]   Plants from Reunion Island with alleged antihypertensive and diuretic effects - an experimental and ethnobotanical evaluation [J].
Adsersen, A ;
Adsersen, H .
JOURNAL OF ETHNOPHARMACOLOGY, 1997, 58 (03) :189-206
[3]   In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle [J].
Asres, K ;
Bucar, F ;
Knauder, E ;
Yardley, V ;
Kendrick, H ;
Croft, SL .
PHYTOTHERAPY RESEARCH, 2001, 15 (07) :613-617
[4]   REPRODUCTIVE-BIOLOGY, VARIABILITY OF NECTAR FEATURES AND POLLINATION OF COMBRETUM-FRUTICOSUM (COMBRETACEAE) IN ARGENTINA [J].
BERNARDELLO, L ;
GALETTO, L ;
RODRIGUEZ, IG .
BOTANICAL JOURNAL OF THE LINNEAN SOCIETY, 1994, 114 (03) :293-308
[5]   Screening the Brazilian flora for antihypertensive plant species for in vitro angiotensin-I-converting enzyme inhibiting activity [J].
Braga, FC ;
Wagner, H ;
Lombardi, JA ;
de Oliveira, AB .
PHYTOMEDICINE, 2000, 7 (03) :245-250
[6]   The angiotensin converting enzyme (ACE) [J].
Coates, D .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2003, 35 (06) :769-773
[7]   New chromanone acids with antibacterial activity from Calophyllum brasiliense [J].
Cottiglia, F ;
Dhanapal, B ;
Sticher, O ;
Heilmann, J .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (04) :537-541
[8]  
da Silva KL, 2001, THERAPIE, V56, P431
[9]   Antioxidant flavonoids and phenolic acids from leaves of Leea guineense G.!Don (Leeaceae) [J].
de Beck, PO ;
Cartier, G ;
David, B ;
Dijoux-Franca, MG ;
Mariotte, AM .
PHYTOTHERAPY RESEARCH, 2003, 17 (04) :345-347
[10]   Enalapril and losartan attenuate mitochondrial dysfunction in aged rats [J].
de Cavanagh, EMV ;
Piotrkowski, B ;
Basso, N ;
Stella, I ;
Inserra, F ;
Ferder, L ;
Fraga, CG .
FASEB JOURNAL, 2003, 17 (06) :1096-+