Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4

被引：27

作者：

Rasolofonjatovo, Evelia ^{[1
]}

Provot, Olivier ^{[1
]}

Hamze, Abdallah ^{[1
]}

Bignon, Jerome ^{[2
]}

Thoret, Sylviane ^{[2
]}

Brion, Jean-Daniel ^{[1
]}

Alami, Mouad ^{[1
]}

机构：

[1] Univ Paris Sud, CNRS, BioCIS, Chim Therapeut Lab,Fac Pharm,UMR 8076, F-92296 Chatenay Malabry, France

[2] CNRS, Inst Chim Subst Nat, UPR 2301, F-91198 Gif Sur Yvette, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 09期

关键词：

Palladium; Alkyne; Ortho-directing effect; Hydrostannation; Olefin; Combretastatin; OXIDE CATALYZED HYDROSILYLATION; ANTINEOPLASTIC AGENTS; STEREOSELECTIVE-SYNTHESIS; ALKYNES; PHOSPHATE; TUBULIN; ANALOGS; CANCER; DRUG; MECHANISMS;

D O I：

10.1016/j.ejmech.2010.05.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：3617 / 3626

页数：10

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