The multiple sclerosis functional composite: different practice effects in the three test components

被引:82
作者
Solari, A [1 ]
Radice, D
Manneschi, L
Motti, L
Montanari, E
机构
[1] Natl Neurol Inst C Besta, Lab Epidemiol, Milan, Italy
[2] Fidenza Hosp, Dept Neurol, Parma, Italy
[3] Arcispedale S Maria Nuova, Dept Neurol, Reggio Emilia, Italy
关键词
multiple sclerosis; outcome measures; clinical trials; timed 25-foot walk; paced auditory serial addition test; 9-hole peg test; reliability; practice effect;
D O I
10.1016/j.jns.2004.09.033
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The multiple sclerosis functional composite (MSFC) is a multidimensional. MS-Specific outcome measure for use in clinical trials, comprising three tests: timed 25-foot walk (T25FW), paced auditory serial addition (PASAT), and 9-hole peg (9HP). Objective: To assess interrater and intrarater reliability and practice/fatigue effects in the MSFC. Methods: The MSFC was administered by two neurologists after a formal training session to 32 MS outpatients. Patients were assessed four times by one examiner and twice by the other. The six tests were administered in a single day, with at least 20 min of rest between them. The examiners were blinded to the results of previous assessments. Testing order was random. Results: Interrater reliability was excellent, with intraclass correlation coefficients (ICC) ranging from 0.93 for 9HP (95% confidence, interval [CI] 0.84-0.96) to 0.99 for T25FW (95% CI 0.97-0.99). For intrarater reliability, ICC ranged from 0.93 for PASAT (95% CI 0.82-0-91) to 0.98 for T25FW (95% CI 0.93-1.00). We found no practice effect for T25FW after the first administration. However, performance improved with testing over the first three sessions for PASAT and over the first four sessions for 9HP. Conclusions: The MSFC is characterised by excellent reliability. Practice effects for the three MSFC components differed being negligible for T25FW and evident for PASAT and 9HP. To improve efficiency, we suggest one prebaseline administration of T25FW three of PASAT and four of 9HP. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:71 / 74
页数:4
相关论文
共 14 条
[1]   STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [J].
BLAND, JM ;
ALTMAN, DG .
LANCET, 1986, 1 (8476) :307-310
[2]   Intrarater and interrater reliability of the MS functional composite outcome measure [J].
Cohen, JA ;
Fischer, JS ;
Bolibrush, DM ;
Jak, AJ ;
Kniker, JE ;
Mertz, LA ;
Skaramagas, TT ;
Cutter, GR .
NEUROLOGY, 2000, 54 (04) :802-806
[3]   Use of the Multiple Sclerosis Functional Composite as an outcome measure in a phase 3 clinical trial [J].
Cohen, JA ;
Cutter, GR ;
Fischer, JS ;
Goodman, AD ;
Heidenreich, FR ;
Jak, AJ ;
Kniker, JE ;
Kooijmans, MF ;
Lull, JM ;
Sandrock, AW ;
Simon, JH ;
Simonian, NA ;
Whitaker, JN .
ARCHIVES OF NEUROLOGY, 2001, 58 (06) :961-967
[4]   Development of a multiple sclerosis functional composite as a clinical trial outcome measure [J].
Cutter, GR ;
Baier, ML ;
Rudick, RA ;
Cookfair, DL ;
Fischer, JS ;
Petkau, J ;
Syndulko, K ;
Weinshenker, BG ;
Antel, JP ;
Confavreux, C ;
Ellison, GW ;
Lublin, F ;
Miller, AE ;
Rao, SM ;
Reingold, S ;
Thompson, A ;
Willoughby, E .
BRAIN, 1999, 122 :871-882
[5]   MULTIPLE COMPARISONS USING RANK SUMS [J].
DUNN, OJ .
TECHNOMETRICS, 1964, 6 (03) :241-&
[6]  
Fisher JS, 1999, MULT SCLER, V5, P244
[7]  
FISHER JS, 1999, ADM SCORING MANUAL M
[8]   MEASURING CHANGE OVER TIME - ASSESSING THE USEFULNESS OF EVALUATIVE INSTRUMENTS [J].
GUYATT, G ;
WALTER, S ;
NORMAN, G .
JOURNAL OF CHRONIC DISEASES, 1987, 40 (02) :171-178
[9]  
KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444
[10]   MEASUREMENT OF OBSERVER AGREEMENT FOR CATEGORICAL DATA [J].
LANDIS, JR ;
KOCH, GG .
BIOMETRICS, 1977, 33 (01) :159-174