Hijacking Solute Carriers for Proton-Coupled Drug Transport

被引：55
作者：
Anderson, Catriona M. H. [1 ]
Thwaites, David T. [1 ]
机构：
[1] Newcastle Univ, Fac Med Sci, Epithelial Res Grp, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源：
PHYSIOLOGY | 2010年 / 25卷 / 06期
基金：
英国惠康基金;
关键词：
BRUSH-BORDER-MEMBRANE; AMINO-ACID TRANSPORTER; REDUCED FOLATE CARRIER; POLYPEPTIDE OATP-B; INTESTINAL CACO-2 CELLS; RENAL PEPTIDE TRANSPORTERS; ORGANIC ANION TRANSPORTER; PH-DEPENDENT TRANSPORT; RAT PROXIMAL JEJUNUM; FUNCTIONAL-CHARACTERIZATION;
D O I：
10.1152/physiol.00027.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The physiological role of mammalian solute carrier (SLC) proteins is to mediate transmembrane movement of electrolytes, nutrients, micronutrients, vitamins, and endogenous metabolites from one cellular compartment to another. Many transporters in the small intestine, kidney, and solid tumors are H+-coupled, driven by local H+-electrochemical gradients, and transport numerous drugs. These transporters include PepT1 and PepT2 (SLC15A1/2), PCFT (SLC46A1), PAT1 (SLC36A1), OAT10 (SLC22A13), OATP2B1 (SLCO2B1), MCT1 (SLC16A1), and MATE1 and MATE2-K (SLC47A1/2).
引用
收藏
页码：364 / 377
页数：14
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