Hijacking Solute Carriers for Proton-Coupled Drug Transport

被引：55
|
作者：
Anderson, Catriona M. H. [1 ]
Thwaites, David T. [1 ]
机构：
[1] Newcastle Univ, Fac Med Sci, Epithelial Res Grp, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源：
PHYSIOLOGY | 2010年 / 25卷 / 06期
基金：
英国惠康基金;
关键词：
BRUSH-BORDER-MEMBRANE; AMINO-ACID TRANSPORTER; REDUCED FOLATE CARRIER; POLYPEPTIDE OATP-B; INTESTINAL CACO-2 CELLS; RENAL PEPTIDE TRANSPORTERS; ORGANIC ANION TRANSPORTER; PH-DEPENDENT TRANSPORT; RAT PROXIMAL JEJUNUM; FUNCTIONAL-CHARACTERIZATION;
D O I：
10.1152/physiol.00027.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The physiological role of mammalian solute carrier (SLC) proteins is to mediate transmembrane movement of electrolytes, nutrients, micronutrients, vitamins, and endogenous metabolites from one cellular compartment to another. Many transporters in the small intestine, kidney, and solid tumors are H+-coupled, driven by local H+-electrochemical gradients, and transport numerous drugs. These transporters include PepT1 and PepT2 (SLC15A1/2), PCFT (SLC46A1), PAT1 (SLC36A1), OAT10 (SLC22A13), OATP2B1 (SLCO2B1), MCT1 (SLC16A1), and MATE1 and MATE2-K (SLC47A1/2).
引用
收藏
页码：364 / 377
页数：14
相关论文
共 46 条
  • [21] Molecular Insights to the Structure-Interaction Relationships of Human Proton-Coupled Oligopeptide Transporters (PepTs)
    Luo, Yining
    Gao, Jingchun
    Jiang, Xukai
    Zhu, Ling
    Zhou, Qi Tony
    Murray, Michael
    Li, Jian
    Zhou, Fanfan
    PHARMACEUTICS, 2023, 15 (10)
  • [22] Expression of proton-coupled oligopeptide transporter (POTs) in prostate of mice and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa)
    Sun, Dongli
    Tan, Fuqing
    Fang, Danbo
    Wang, Yuqing
    Zeng, Su
    Jiang, Huidi
    PROSTATE, 2013, 73 (03): : 287 - 295
  • [23] Identification of the amino acid residue responsible for the myricetin sensitivity of human proton-coupled folate transporter
    Yamashiro, Takahiro
    Yasujima, Tomoya
    Ohta, Kinya
    Inoue, Katsuhisa
    Yuasa, Hiroaki
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [24] THYROTROPIN-RELEASING-HORMONE (TRH) UPTAKE IN INTESTINAL BRUSH-BORDER MEMBRANE-VESICLES - COMPARISON WITH PROTON-COUPLED DIPEPTIDE AND NA+-COUPLED GLUCOSE-TRANSPORT
    THWAITES, DT
    SIMMONS, NL
    HIRST, BH
    PHARMACEUTICAL RESEARCH, 1993, 10 (05) : 667 - 673
  • [25] Impact of nanodisc lipid composition on cell-free expression of proton-coupled folate transporter
    Do, Hoa Quynh
    Bassil, Carla M.
    Andersen, Elizabeth, I
    Jansen, Michaela
    PLOS ONE, 2021, 16 (11):
  • [26] Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)
    Huttunen, Johanna
    Adla, Santosh Kumar
    Markowicz-Piasecka, Magdalena
    Huttunen, Kristiina M.
    PHARMACEUTICS, 2022, 14 (06)
  • [27] The Functional Roles of the His247 and His281 Residues in Folate and Proton Translocation Mediated by the Human Proton-coupled Folate Transporter SLC46A1
    Unal, Ersin Selcuk
    Zhao, Rongbao
    Chang, Min-Hwang
    Fiser, Andras
    Romero, Michael F.
    Goldman, I. David
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (26) : 17846 - 17857
  • [28] Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells
    Zebisch, Katja
    Brandsch, Matthias
    AMINO ACIDS, 2013, 44 (02) : 373 - 381
  • [29] SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1
    Tomabechi, Ryuto
    Kishimoto, Hisanao
    Sato, Taeka
    Saito, Naoki
    Kiyomiya, Keisuke
    Takada, Tappei
    Higuchi, Kei
    Shirasaka, Yoshiyuki
    Inoue, Katsuhisa
    PNAS NEXUS, 2022, 1 (03):
  • [30] Inhibition of the Proton-Coupled Folate Transporter (PCFT-SLC46A1) by Bicarbonate and Other Anions
    Zhao, Rongbao
    Visentin, Michele
    Suadicani, Sylvia O.
    Goldman, I. David
    MOLECULAR PHARMACOLOGY, 2013, 84 (01) : 95 - 103
12345