Hijacking Solute Carriers for Proton-Coupled Drug Transport

被引：55
|
作者：
Anderson, Catriona M. H. [1 ]
Thwaites, David T. [1 ]
机构：
[1] Newcastle Univ, Fac Med Sci, Epithelial Res Grp, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源：
PHYSIOLOGY | 2010年 / 25卷 / 06期
基金：
英国惠康基金;
关键词：
BRUSH-BORDER-MEMBRANE; AMINO-ACID TRANSPORTER; REDUCED FOLATE CARRIER; POLYPEPTIDE OATP-B; INTESTINAL CACO-2 CELLS; RENAL PEPTIDE TRANSPORTERS; ORGANIC ANION TRANSPORTER; PH-DEPENDENT TRANSPORT; RAT PROXIMAL JEJUNUM; FUNCTIONAL-CHARACTERIZATION;
D O I：
10.1152/physiol.00027.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The physiological role of mammalian solute carrier (SLC) proteins is to mediate transmembrane movement of electrolytes, nutrients, micronutrients, vitamins, and endogenous metabolites from one cellular compartment to another. Many transporters in the small intestine, kidney, and solid tumors are H+-coupled, driven by local H+-electrochemical gradients, and transport numerous drugs. These transporters include PepT1 and PepT2 (SLC15A1/2), PCFT (SLC46A1), PAT1 (SLC36A1), OAT10 (SLC22A13), OATP2B1 (SLCO2B1), MCT1 (SLC16A1), and MATE1 and MATE2-K (SLC47A1/2).
引用
收藏
页码：364 / 377
页数：14
相关论文
共 50 条
  • [1] PROTON-COUPLED TRANSPORT MECHANISMS IN BACTERIA
    WEST, IC
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1974, 2 (05) : 800 - 803
  • [2] FUNDAMENTAL FEATURES OF PROTON-COUPLED TRANSPORT
    WILLIAMS, RJP
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1977, 5 (01) : 29 - 32
  • [3] The molecular physiology of sodium- and proton-coupled solute transporters
    Steel, A
    Hediger, MA
    NEWS IN PHYSIOLOGICAL SCIENCES, 1998, 13 : 123 - 131
  • [4] Effect of Epigallocatechin Gallate on Drug Transport Mediated by the Proton-coupled Folate Transporter
    Kissei, Maika
    Itoh, Tomoo
    Narawa, Tomoya
    DRUG METABOLISM AND PHARMACOKINETICS, 2014, 29 (05) : 367 - 372
  • [5] PROTON-COUPLED TRANSPORT-SYSTEMS AT THE TONOPLAST
    POOLE, RJ
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 76 - 76
  • [6] PERFORMANCE AND CONSERVATION OF OSMOTIC WORK BY PROTON-COUPLED SOLUTE PORTER SYSTEMS
    MITCHELL, P
    JOURNAL OF BIOENERGETICS, 1973, 4 (1-2): : 63 - 91
  • [7] Proton-coupled transport mechanism of the efflux pump NorA
    Li, Jianping
    Li, Yan
    Koide, Akiko
    Kuang, Huihui
    Torres, Victor J.
    Koide, Shohei
    Wang, Da-Neng
    Traaseth, Nathaniel J.
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [8] PROTON-COUPLED HEXOSE TRANSPORT IN CHLORELLA-VULGARIS
    KOMOR, E
    FEBS LETTERS, 1973, 38 (01) : 16 - 18
  • [9] Controlling the Rate and Efficiency of Proton-Coupled Transport by EmrE
    Thomas, Nathan
    Wu, Chao
    Spreacker, Peyton
    Hussey, Grant
    Wynne, Samantha
    Uhlemann, Eva-Maria
    Tate, Christopher
    DeKoster, Gregory T.
    Henzler-Wildman, Katherine
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 2A - 2A
  • [10] Proton-coupled protein transport through the anthrax toxin channel
    Finkelstein, Alan
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2009, 364 (1514) : 209 - 215
12345