Vanadium induces AP-1- and NFκB-dependent transcription activity

被引：0

作者：

Huang, CS ^{[1
]}

Chen, NY ^{[1
]}

Ma, WY ^{[1
]}

Dong, ZG ^{[1
]}

机构：

[1] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 1998年 / 13卷 / 04期

关键词：

vanadium; AP-1; NF kappa B;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NF kappa-B activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NF kappa B appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly increased at 100 mu M of vanadate. while phosphorylation of JNKs was not affected, Vanadate also enhances the phosphorylation of I kappa B alpha. These results suggest that the activation of AP-1 and NF kappa B by vanadate may be mediated through enhancement of phosphorylation of Erk/p38 kinases and I kappa B alpha. respectively.

引用

页码：711 / 715

页数：5

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