Vanadium induces AP-1- and NFκB-dependent transcription activity

被引：0

作者：

Huang, CS ^{[1
]}

Chen, NY ^{[1
]}

Ma, WY ^{[1
]}

Dong, ZG ^{[1
]}

机构：

[1] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 1998年 / 13卷 / 04期

关键词：

vanadium; AP-1; NF kappa B;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NF kappa-B activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NF kappa B appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly increased at 100 mu M of vanadate. while phosphorylation of JNKs was not affected, Vanadate also enhances the phosphorylation of I kappa B alpha. These results suggest that the activation of AP-1 and NF kappa B by vanadate may be mediated through enhancement of phosphorylation of Erk/p38 kinases and I kappa B alpha. respectively.

引用

页码：711 / 715

页数：5

共 50 条

[21] Thioredoxin and its involvement in the redox regulation of transcription factors, NF-κB and AP-1
Ohno, T
Hirota, K
Nakamura, H
Masutani, H
Sasada, T
Yodoi, J
OXYGEN HOMEOSTASIS AND ITS DYNAMICS, 1998, 1 : 450 - 456
[22] CysLT1 receptor engagement induces activator protein-1-and NF-κB-dependent IL-8 expression
Thompson, Charles
Cloutier, Alexandre
Bosse, Ynuk
Thivierge, Maryse
Le Gouill, Christian
Larivee, Pierre
McDonald, Patrick P.
Stankova, Jana
Rola-Pleszczynski, Marek
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2006, 35 (06) : 697 - 704
[23] CARM1 but not Its Enzymatic Activity Is Required for Transcriptional Coactivation of NF-κB-Dependent Gene Expression
Jayne, Sandrine
Rothgiesser, Karin M.
Hottiger, Michael O.
JOURNAL OF MOLECULAR BIOLOGY, 2009, 394 (03) : 485 - 495
[24] Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-κB-dependent transcription
Hofmann, TG
Hehner, SP
Bacher, S
Dröge, W
Schmitz, ML
FEBS LETTERS, 1998, 441 (03) : 441 - 446
[25] Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NFκB-Dependent Mechanism
McKenna, Sarah
Eckman, Molly
Parker, Andrew
Bok, Rachael
Hurt, K. Joseph
Wright, Clyde J.
JOURNAL OF INNATE IMMUNITY, 2016, 8 (04) : 386 - 399
[26] Intermittent hypoxia induces NF-κB-dependent endothelial activation via adipocyte-derived mediators
Lee, Mary Y. K.
Wang, Yan
Mak, Judith C. W.
Ip, Mary S. M.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2016, 310 (06): : C446 - C455
[27] Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells
Holden, N. S.
Gong, W.
King, E. M.
Kaur, M.
Giembycz, M. A.
Newton, R.
BRITISH JOURNAL OF PHARMACOLOGY, 2007, 152 (06) : 891 - 902
[28] Benzo[a]pyrene-dependent activation of transcription factors NF-κB and AP-1 related to tumor promotion in hepatoma cell cultures
Bolotina, N. A.
Gasparian, A. V.
Dubovaja, T. K.
Evteev, V. A.
Kobliakov, V. A.
BIOCHEMISTRY-MOSCOW, 2007, 72 (05) : 552 - 557
[29] Activator protein 1 (AP-1)- and nuclear factor κB (NF-κB)-dependent transcriptional events in carcinogenesis
Hsu, TC
Young, MR
Cmarik, J
Colburn, NH
FREE RADICAL BIOLOGY AND MEDICINE, 2000, 28 (09) : 1338 - 1348
[30] Transcription of the caspase-14 gene in human epiderma keratinocytes requires AP-1 and NFκB
Ballaun, Claudia
Karner, Susanne
Mrass, Paul
Mildner, Michael
Buchberger, Maria
Bach, Juergen
Ban, Jozef
Harant, Hanna
Tschachler, Erwin
Eckharta, Leopold
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 371 (02) : 261 - 266

← 1 2 3 4 5 →