Versatile Synthesis of Fused Tricyclic 1,2,4-Triazole Derivatives

被引：5
|
作者：
Ellis, David [1 ]
机构：
[1] Pfizer Global Res & Dev, Discovery Chem, Sandwich CT13 9NJ, Kent, England
来源：
SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 07期
关键词：
Fused tricyclic ring system; intramolecular reduction cyclization; Suzuki reaction; 1,2,4-triazole; vicarious nucleophilic substitution;
D O I：
10.1080/00397911003707170
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[image omitted] The synthesis of a small series of fused tricyclic 1,2,4-triazoles is described. The key reaction is an intramolecular two-stage, one-pot reduction/cyclization sequence of a nitropyridine/oxadiazole substrate to give the key tricyclic triazole. Further standard transformations convert this template into a series of final target compounds.
引用
收藏
页码：963 / 975
页数：13
相关论文
共 50 条
  • [21] Synthesis of sulfonyl and sulfenyl derivatives of pyridine and 1,2,4-triazole
    Anisimov, A. V.
    Fedorova, E. V.
    Tarakanova, A. V.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2006, 42 (06) : 918 - 921
  • [22] SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NOVEL 1,2,4-TRIAZOLE DERIVATIVES
    Yashaswini, K.
    Revanasiddappa, B. C.
    Kumar, M. Vijay
    Kumar, Hemanth
    HETEROCYCLIC LETTERS, 2018, 8 (03): : 613 - 617
  • [23] Synthesis and antioxidant activity of new 1,2,4-triazole derivatives
    T. V. Kochikyan
    M. A. Samvelyan
    E. V. Arutyunyan
    V. S. Arutyunyan
    A. A. Avetisyan
    M. G. Malakyan
    L. A. Vardevanyan
    S. A. Badzhinyan
    Pharmaceutical Chemistry Journal, 2011, 44 : 525 - 527
  • [24] Synthesis and rheological activity of new 1,2,4-triazole derivatives
    Klen E.E.
    Khaliullin F.A.
    Spasov A.A.
    Makarova N.N.
    Bagautdinova L.F.
    Naumenko L.V.
    Pharmaceutical Chemistry Journal, 2008, 42 (9) : 510 - 512
  • [25] Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives
    El-Sayed, R
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2006, 45 (03): : 738 - 746
  • [26] SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NEW 1,2,4-TRIAZOLE DERIVATIVES
    Kochikyan, T. V.
    Samvelyan, M. A.
    Arutyunyan, E. V.
    Arutyunyan, V. S.
    Avetisyan, A. A.
    Malakyan, M. G.
    Vardevanyan, L. A.
    Badzhinyan, S. A.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2011, 44 (10) : 525 - 527
  • [27] FUSED MESOIONIC HETEROCYCLES - SYNTHESIS OF 1,2,4-TRIAZOLO(4,3-B)-1,2,4-TRIAZOLE DERIVATIVES
    MOLINA, P
    LORENZO, A
    CLARAMUNT, RM
    ELGUERO, J
    TETRAHEDRON LETTERS, 1984, 25 (47) : 5427 - 5428
  • [28] SYNTHESIS OF 2,5-DIBROMO-1,2,4-TRIAZOLE BY BROMINATION OF 1,2,4-TRIAZOLE [1]
    KROGER, CF
    FRANK, H
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1965, 4 (05) : 434 - &
  • [29] Antitumor activity and synthesis of new derivatives with fused ring system of 1,2,4-triazole scaffold and their characterization
    Slaihim, Mukhlif Mohsin
    Al-Suede, Fouad Saleih R.
    Khairuddean, Melati
    Sultan, Siti Balkees S. T. N. Hameed
    Mansoureh Nazari, V
    Ahamed, Mohamed B. Khadeer
    Majid, Amin Malik Shah Abdul
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1289
  • [30] Synthesis of 1,2,4-triazole dendrimers
    Maes, W
    Verstappen, B
    Dehaen, W
    TETRAHEDRON, 2006, 62 (11) : 2677 - 2683
12345