Versatile Synthesis of Fused Tricyclic 1,2,4-Triazole Derivatives

被引：5
|
作者：
Ellis, David [1 ]
机构：
[1] Pfizer Global Res & Dev, Discovery Chem, Sandwich CT13 9NJ, Kent, England
来源：
SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 07期
关键词：
Fused tricyclic ring system; intramolecular reduction cyclization; Suzuki reaction; 1,2,4-triazole; vicarious nucleophilic substitution;
D O I：
10.1080/00397911003707170
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[image omitted] The synthesis of a small series of fused tricyclic 1,2,4-triazoles is described. The key reaction is an intramolecular two-stage, one-pot reduction/cyclization sequence of a nitropyridine/oxadiazole substrate to give the key tricyclic triazole. Further standard transformations convert this template into a series of final target compounds.
引用
收藏
页码：963 / 975
页数：13
相关论文
共 50 条
  • [11] BENZOTHIAZOLES DERIVATIVES OF 1,2,4-TRIAZOLE
    RUSSO, F
    SANTAGAT.M
    PAPPALAR.G
    ANNALI DI CHIMICA, 1972, 62 (05) : 351 - &
  • [12] ACETYLENE DERIVATIVES OF 1,2,4-TRIAZOLE
    VASILEVSKII, SF
    SINYAKOV, AN
    SHVARTSBERG, MS
    KOTLYAREVSKII, IL
    BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR DIVISION OF CHEMICAL SCIENCE, 1975, 24 (03): : 616 - 619
  • [13] DERIVATIVES OF 1,2,4-TRIAZOLE AND OF PYRAZOLE
    SHARP, DB
    HAMILTON, CS
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1946, 68 (04) : 588 - 591
  • [14] Synthesis of 1,2,4-Triazole Derivatives and Determination of Protonation Constant
    Islamoglu, Fatih
    Kahveci, Bahittin
    Bekircan, Olcay
    ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (07) : 5523 - 5534
  • [15] Synthesis of 1,2,4-Triazole Benzamide Derivatives and Fungicidal Activity
    Jiang, Zhenhua
    Cheng, Yi'nan
    Shen, Guofu
    Zhang, Mengmeng
    Su, Ziyang
    Sun, Liansheng
    Li, Honglian
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 40 (08) : 2575 - 2582
  • [16] Synthesis and characterization of substituted 1,2,4-Triazole and its derivatives
    Jadhav, Shivaji
    Rai, Megha
    Durrani, Ayesha
    Bembalkar, S. R.
    ORIENTAL JOURNAL OF CHEMISTRY, 2010, 26 (02) : 725 - 728
  • [17] Synthesis and Characterization of Substituted 1,2,4-Triazole and Its Derivatives
    Jadhav, Shivaji
    Rai, Megha
    Khillare, Lalit
    Durrani, Ayesha
    ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (06) : 4245 - 4248
  • [18] Synthesis of sulfonyl and sulfenyl derivatives of pyridine and 1,2,4-triazole
    A. V. Anisimov
    E. V. Fedorova
    A. V. Tarakanova
    Russian Journal of Organic Chemistry, 2006, 42 : 918 - 921
  • [19] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1,2,4-TRIAZOLE DERIVATIVES
    TALAWAR, MB
    LADDI, UV
    SOMANNAVAR, YS
    BENNUR, RS
    BENNUR, SC
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 4 (04) : 297 - 300
  • [20] A Review on Chemistry and Methods of Synthesis of 1,2,4-Triazole Derivatives
    Rodrigues, Searitha Couto
    de Moraes, Raphael Silva Moratorio
    Pinto, Gabriel Tavares de Almeida
    Martins, Maria Tereza Miranda
    do Nascimento, Patrick Antunes
    Soares, Deivid Lucas Alves
    Botelho, Ana Beatriz Mestre
    Cruz, Camille Cardoso
    Cunha, Anna Claudia
    CHEMICAL RECORD, 2025, 25 (01):
12345