Obesity II: Establishing causal links between chemical exposures and obesity

被引：116

作者：

Heindel, Jerrold J. ^{[1
]}

Howard, Sarah ^{[1
]}

Agay-Shay, Keren ^{[2
]}

Arrebola, Juan P. ^{[3
]}

Audouze, Karine ^{[4
]}

Babin, Patrick J. ^{[5
]}

Barouki, Robert ^{[6
]}

Bansal, Amita ^{[7
]}

Blanc, Etienne ^{[6
]}

Cave, Matthew C. ^{[8
]}

Chatterjee, Saurabh ^{[9
]}

Chevalier, Nicolas ^{[10
]}

Choudhury, Mahua ^{[11
]}

Collier, David ^{[12
]}

Connolly, Lisa ^{[13
]}

Coumoul, Xavier

Garruti, Gabriella ^{[14
]}

Gilbertson, Michael ^{[15
]}

Hoepner, Lori A. ^{[16
]}

Holloway, Alison C. ^{[17
]}

Howell, George, III ^{[5
,7
,18
]}

Kassotis, Christopher D. ^{[5
,7
,19
]}

Kay, Mathew K. ^{[5
,7
]}

Kim, Min Ji ^{[5
,7
,20
]}

Lagadic-Gossmann, Dominique ^{[4
,5
,7
,32
]}

Langouet, Sophie ^{[4
,5
,7
,32
]}

Legrand, Antoine ^{[5
,7
]}

Li, Zhuorui ^{[5
,7
,21
]}

Le Mentec, Helene ^{[5
,7
]}

Lind, Lars ^{[5
,7
,22
]}

Lind, P. Monica ^{[5
,7
,23
]}

Lustig, Robert H. ^{[5
,7
,24
]}

Martin-Chouly, Corinne ^{[5
,7
]}

Kos, Vesna Munic ^{[5
,7
,25
]}

Podechard, Normand ^{[5
,7
]}

Roepke, Troy A. ^{[5
,7
,26
]}

Sargis, RobertM. ^{[5
,7
,27
]}

Starling, Anne ^{[5
,7
,28
]}

Tomlinson, Craig R. ^{[5
,7
,29
]}

Touma, Charbel ^{[5
,7
]}

Vondracek, Jan ^{[2
,5
,7
,30
]}

vom Saal, Frederick ^{[3
,7
,31
]}

Blumberg, Bruce ^{[5
,7
]}

机构：

[1] Hlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA

[2] Univ Paris, Dept Syst Biol & Bioinformat, INSERM, T3S, Paris, France

[3] Univ Bordeaux, Dept Life & Hlth Sci, INSERM, Pessac, France

[4] Univ Paris, Dept Biochem, INSERM, T3S, F-75006 Paris, France

[5] Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA

[6] Univ South Carolina, Environm Hlth & Dis Lab, Columbia, SC 29208 USA

[7] Univ Cote Azur, Obstet & Gynecol, Cote Azur, France

[8] Texas A&M Univ, Coll Pharm, College Stn, TX 77843 USA

[9] Univ Bari Aldo Moro, Dept Endocrinol, Bari, Italy

[10] East Carolina Univ, Brody Sch Med, Greenville, NC 27834 USA

[11] Queens Univ, Inst Global Food Secur, Sch Biol Sci, Belfast, North Ireland

[12] Univ Stirling, Occupat & Environm Hlth Res Grp, Stirling, Scotland

[13] Bar Ilan Univ, Azrieli Fac Med, Hlth & Environm Res HER Lab, Ramat Gan, Israel

[14] Publ Hlth Univ Granada, Dept Prevent Med, Granada, Spain

[15] Australian Natl Univ, Coll Hlth & Med, Canberra, Australia

[16] SUNY Downstate Hlth Sci Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Brooklyn, NY 11203 USA

[17] McMaster Univ, Dept Obstet & Gynecol, Ontario, CA USA

[18] Mississippi State Univ, Ctr Environm Hlth Sci, Starkville, MS 39762 USA

[19] Wayne State Univ, Inst Environm Hlth Sci, Dept Pharmacol, Detroit, MI 48202 USA

[20] Sorbonne Paris Nord Univ, INSERM U1124 T3S, Bobigny, Paris, France

[21] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA

[22] Uppsala Univ, Uppsala Univ Hosp, Dept Med Sci, Clin Epidemiol, Uppsala, Sweden

[23] Uppsala Univ, Uppsala Univ Hosp, Dept Med Sci, Occupat & Environm Med, Uppsala, Sweden

[24] Univ Calif San Francisco, Dept Pediat, Div Endocrinol, San Francisco, CA 94143 USA

[25] Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden

[26] Rutgers State Univ, Sch Environm & Biol Sci, Dept Anim Sci, New Brunswick, NJ 08901 USA

[27] Univ Illinois, Div Endocrinol Diabet & Metab, Chicago, IL 60612 USA

[28] Univ North Carolina Chapel Hill, Dept Epidemiol, Chapel Hill, NC 27599 USA

[29] Norris Cotton Canc Ctr, Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, Lebanon, NH 03756 USA

[30] Inst Biophys Czech Acad Sci, Dept Cytokinet, Brno, Czech Republic

[31] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA

[32] Univ Rennes, INSERM EHESP, IRSET UMR 5S 1085, F-35000 Rennes, France

来源：

BIOCHEMICAL PHARMACOLOGY | 2022年 / 199卷

基金：

欧盟地平线“2020”; 加拿大健康研究院;

关键词：

Obesogen; Adipocyte differentiation; Weight gain; Obesity; Endocrine disruptor; PERSISTENT ORGANIC POLLUTANTS; ENDOCRINE-DISRUPTING CHEMICALS; ACTIVATED-RECEPTOR-GAMMA; AMBIENT AIR-POLLUTION; ORGANOPHOSPHATE FLAME-RETARDANTS; BODY-MASS INDEX; ARYL-HYDROCARBON RECEPTOR; NONALCOHOLIC FATTY LIVER; BENZYL BUTYL PHTHALATE; FARNESOID-X-RECEPTOR;

D O I：

10.1016/j.bcp.2022.115015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.

引用

页数：49

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