Bismuth(III) and diorganotin(IV) complexes of bis(2-acetylpyridine) thiocarbonohydrazone: Synthesis, characterization, and apoptosis mechanism of action in vitro

被引：15

作者：

Fang, Yan ^{[1
]}

Wang, Yu-Ting ^{[2
]}

Zhao, Meng ^{[1
]}

Lu, Yan-Li ^{[1
]}

Li, Ming-Xue ^{[1
]}

Zhang, Ya-Hong ^{[3
]}

机构：

[1] Henan Univ, Henan Key Lab Polyoxometalates, Inst Mol & Crystal Engn, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China

[2] Henan Finance Univ, Coll Chem & Environm, Zhengzhou 450046, Henan, Peoples R China

[3] Henan Univ, Key Lab Nat Med & Immune Engn, Kaifeng 475004, Peoples R China

来源：

POLYHEDRON | 2018年 / 155卷

基金：

中国国家自然科学基金;

关键词：

Thiosemicarbazone; Complex; Crystal structure; Cytotoxicity; Apoptosis mechanism; CRYSTAL-STRUCTURE; ORGANOTIN(IV) COMPLEXES; BIOLOGICAL EVALUATION; SPECTROSCOPIC CHARACTERIZATION; SPECTRAL CHARACTERIZATION; ANTICANCER ACTIVITY; SCHIFF-BASE; 2-ACETYLPYRIDINE; CHEMISTRY; N(4)-PHENYLTHIOSEMICARBAZONE;

D O I：

10.1016/j.poly.2018.08.049

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In this paper, three bismuth(III) and diorganotin(IV) complexes based on bis(2-acetylpyridine) thiocarbonohydrazone (H2L) have been fully designed. The tests of the complexes on inhibiting human hepatocellular carcinoma HepG2 cells growth in vitro revealed that the complexes have higher activity against HepG2 cells but much less toxicity toward normal hepatocyte QSG7701 cells. Particularly, 1 exhibited higher activity with a lower IC50 value (compound concentration that produces 50% of cell death, 3.42 +/- 0.25 mu M). Moreover, cytotoxicity experiments involving with mitochondria confirmed that 1 restrained cells growth in a dose-dependent manner. Protein analysis indicated that 1 restrained Bcl-2 expression and accelerated Bax expression, inducing caspase-3 activation. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：254 / 260

页数：7

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