Fasting Indicators of Insulin Sensitivity: Effects of Ethnicity and Pubertal Status

被引:16
作者
Adam, Tanja C. [1 ]
Hasson, Rebecca E. [2 ]
Lane, Christianne J. [1 ]
Davis, Jaimie N. [1 ]
Weigensberg, Marc J. [3 ]
Spruijt-Metz, Donna [1 ]
Goran, Michael I. [1 ]
机构
[1] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
[2] Univ Calif San Francisco, Ctr Social Dispar Hlth, Dept Family & Community Med, San Francisco, CA 94143 USA
[3] Univ So Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA
关键词
BETA-CELL FUNCTION; DIABETES-MELLITUS; HISPANIC CHILDREN; AFRICAN-AMERICAN; GLUCOSE CLAMP; MINIMAL MODEL; DISEASE RISK; RESISTANCE; OVERWEIGHT; OBESITY;
D O I
10.2337/dc10-1593
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-To examine the relationship of fasting indicators of insulin sensitivity with a more invasive measure of insulin sensitivity (frequently sampled intravenous glucose tolerance test [FSIVGTT]) and the effect of Tanner stage and ethnicity on that relationship. RESEARCH DESIGN AND METHODS-Data were analyzed from 149 overweight girls (97 Hispanic and 52 African American) who were either in the early stages of maturation defined by Tanner stages 1 or 2 (52 Hispanic and 18 African American) or in the later stages of maturation defined by Tanner stages 4 and 5 (45 Hispanic and 34 African American). Fasting indicators of insulin sensitivity (IS) included fasting insulin and glucose and the homeostasis model assessment of insulin resistance (HOMA-IR). IS was derived from an FSIVGTT with minimal modeling. RESULTS-In Tanner stages 1 and 2, all fasting indicators were significantly associated with IS: (fasting insulin: r = -0.67, P < 0.01; HOMA: r = -0.66, P < 0.01) with no significant influence of ethnicity on these relationships. In Tanner stages 4 and 5, however, all fasting indicators were associated with IS in African American girls (fasting insulin: r = -0.55, P < 0.01; HOMA: r = -0.47, P < 0.01), but none of the indicators were significantly associated with IS in Hispanic girls. CONCLUSIONS-Fasting indicators were reflective of IS for girls in Tanner stages 1 and 2, regardless of ethnicity and may provide a clinical measure of future risk for type 2 diabetes. In the latter stages of maturation, however, more invasive measures are warranted to adequately determine IS in clinical practice.
引用
收藏
页码:994 / 999
页数:6
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