DAF-16/Forkhead Box O Transcription Factor: Many Paths to a Single Fork(head) in the Road

被引：62

作者：

Yen, Kelvin ^{[1
]}

Narasimhan, Devi ^{[1
]}

Tissenbaum, Heidi A. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Program Gene Funct & Express, Program Mol Med, Worcester, MA 01605 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 14卷 / 04期

关键词：

PROTEIN-KINASE-B; REGULATES LIFE-SPAN; C-ELEGANS DAF-16; CAENORHABDITIS-ELEGANS; SIGNALING PATHWAY; STRESS RESISTANCE; DAUER FORMATION; MOLECULAR CHAPERONES; MEDIATES LONGEVITY; LARVAL DEVELOPMENT;

D O I：

10.1089/ars.2010.3490

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Caenorhabditis elegans Forkhead box O transcription factor (FOXO) homolog DAF-16 functions as a central mediator of multiple biological processes such as longevity, development, fat storage, stress resistance, and reproduction. In C. elegans, similar to other systems, DAF-16 functions as the downstream target of a conserved, well-characterized insulin/insulin-like growth factor (IGF)-1 signaling pathway. This cascade is comprised of an insulin/IGF-1 receptor, which signals through a conserved PI 3-kinase/AKT pathway that ultimately down-regulates DAF-16/FOXO activity. Importantly, studies have shown that multiple pathways intersect with the insulin/IGF-1 signaling pathway and impinge on DAF-16 for their regulation. Therefore, in C. elegans, the single FOXO family member, DAF-16, integrates signals from several pathways and then regulates its many downstream target genes. Antioxid. Redox Signal. 14, 623-634.

引用

页码：623 / 634

页数：12