Safety and tolerability of once or twice daily neutral protamine hagedorn insulin in fasting pregnant women with diabetes during Ramadan

被引:11
作者
Azlin, Mohamed I. Nor [1 ]
Adam, Rohaida [1 ]
Sufian, Seri S. [1 ]
Wahab, Norashikin A. [2 ]
Mustafa, Norlaila [2 ]
Kamaruddin, Nor A. [2 ]
Jamil, Muhammad A. [1 ]
机构
[1] Univ Kebangsaan Malaysia, Dept Obstet & Gynaecol, Fac Med, Kuala Lumpur 56000, Malaysia
[2] Univ Kebangsaan Malaysia, Dept Med, Fac Med, Kuala Lumpur 56000, Malaysia
关键词
diabetes; fasting; insulin; pregnancy; Ramadan;
D O I
10.1111/j.1447-0756.2010.01330.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aim: To evaluate the safety and tolerability of once or twice daily neutral protamine hagedorn (NPH) insulin in fasting pregnant diabetics during Ramadan. Methods: This was a prospective cohort study conducted during Ramadan 2006 and 2007. Twenty four pregnant diabetic women were given NPH insulin once at 5 pm or twice daily at 5 pm and 5 am. Demographic data, blood glucose control, insulin requirement, days of fasting and hypoglycemic episodes were analyzed. Results: Most women were parity 1 (37.5%) in their second trimester (54.2%) and worked during the daytime (87.5%). Fourteen women (58.3%) had gestational diabetes mellitus, nine women (37.5%) had type 2 and one (4.2%) had type 1 diabetes mellitus. There were significant reductions in mean fasting blood glucose (6.16 mmol/L versus 5.34 mmol/L, P = 0.001), glycosylated hemoglobin (HbA1c) (6.70% +/- 0.91 versus 6.64% +/- 0.96, P = 0.001) and serum fructosamine (232.4 mmol/L +/- 24.0 versus 217.0 mmol/L +/- 24.3, P = 0.001) after Ramadan compared to before Ramadan. Throughout the four weeks of Ramadan, home blood glucose monitoring showed a reducing trend and was within the acceptable limits. Insulin requirement was increased from the first to the fourth week with a reduction in insulin dose noted after (38.5 U/day) compared to before the start of Ramadan (40 U/day). Most women (79.2%) were able to fast for more than 15 days without any hypoglycemia or fetal demise. Conclusion: Once or twice daily NPH insulin is a safe and tolerable option for pregnant diabetics who wish to fast during Ramadan.
引用
收藏
页码:132 / 137
页数:6
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