Effect of Losartan and Ramipril on Oxidative stress and Anti-oxidant Status in South Indian Hypertensive Patients

Over production of oxygen free radicals, which is mainly mediated by super oxide, occurs in human hypertension. Ramipril and losartan are the drugs which found to be more prescribed drugs for hypertension patients. In the present study, an attempt has been made to evaluate the levels of serum Glutathione, Total anti-oxidant status, lipid peroxidation (malondialdehide) and liver function parameters like serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase. Total 75 subjects were selected for study. Out of 75 subjects 25 were normal healthy volunteers and 50 subjects were patients who are untreated with hypertension. The patients both male and female within the age group of 25-65 years were selected. Glutathione, total anti oxidant status, lipid peroxidation, serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase levels in plasma were estimated by using reported methods. Individual methods were standardized first and standard graphs were plotted and the parameters were measured significantly decreased values of glutathione, total anti oxidant status and malondialdehide were observed (p<0.001) in untreated hypertension patients as compared with normal healthy volunteers. After therapy there was significant (p<0.001) increase in the glutathione, total oxidant status and malondialdehide as compared with untreated patients. The results indicates that further extensive studies are required to understand the molecular level mechanism of losartan and ramipril in oxidative stress in hypertensive patients.