Roles of RUNX in Solid Tumors

被引：19

作者：

Chuang, Linda Shyue Huey ^{[1
]}

Ito, Kosei ^{[2
]}

Ito, Yoshiaki ^{[1
]}

机构：

[1] Natl Univ Singapore, Ctr Translat Med, Canc Sci Inst Singapore, 14 Med Dr 12-01, Singapore 117599, Singapore

[2] Nagasaki Univ, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528588, Japan

来源：

RUNX PROTEINS IN DEVELOPMENT AND CANCER | 2017年 / 962卷

关键词：

RUNX; Solid tumors; Tumor suppressor; Oncogene; Wnt; TGF beta; RAS; Senescence; Protein-protein interaction; Stress-inducible gene; Precancerous state; Intestinal metaplasia; GASTRIC EPITHELIAL-CELLS; TRANSCRIPTION FACTOR RUNX; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; PROTEIN MISLOCALIZATION; CAENORHABDITIS-ELEGANS; LINEAGE COMMITMENT; COLORECTAL-CANCER; ESTROGEN-RECEPTOR; SUPPRESSOR GENE;

D O I：

10.1007/978-981-10-3233-2_19

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

All RUNX genes have been implicated in the development of solid tumors, but the role each RUNX gene plays in the different tumor types is complicated by multiple interactions with major signaling pathways and tumor heterogeneity. Moreover, for a given tissue type, the specific role of each RUNX protein is distinct at different stages of differentiation. A regulatory function for RUNX in tissue stem cells points sharply to a causal effect in tumorigenesis. Understanding how RUNX dysregulation in cancer impinges on normal biological processes is important for identifying the molecular mechanisms that lead to malignancy. It will also indicate whether restoration of proper RUNX function to redirect cell fate is a feasible treatment for cancer. With the recent advances in RUNX research, it is time to revisit the many mechanisms/pathways that RUNX engage to regulate cell fate and decide whether cells proliferate, differentiate or die.

引用

页码：299 / 320

页数：22

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