Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in "real-world" settings

被引：5

作者：

Weng, Nan-Ping ^{[1
]}

Pawelec, Graham ^{[2
,3
]}

机构：

[1] NIA, Lab Mol Biol & Immunol, NIH, Baltimore, MD 21224 USA

[2] Univ Tubingen, Dept Immunol, Tubingen, Germany

[3] Hlth Sci North Res Inst, Sudbury, ON, Canada

来源：

IMMUNITY & AGEING | 2021年 / 18卷 / 01期

关键词：

SARS-CoV-2; Vaccination; COVID-19; Longevity of vaccine response; Neutralizing mAb; Aging; COVID-19;

D O I：

10.1186/s12979-021-00248-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The rapidity of SARS-CoV-2 vaccination around the world has substantially reduced the number of new cases of COVID-19 and their severity in highly vaccinated countries. The unanticipated efficacy of SARS-CoV-2 vaccines in older adults has been very encouraging but the longevity of vaccine immunity is currently unknown and protection against emerging variants may be lower. Adoptive immunotherapy with neutralizing mAb may offer an alternative for poor vaccine responders, while the mechanisms underlying failure to respond are still unclear. Further studies of B and T cell responses and their regulation particularly in older populations will provide a more solid foundation to develop suitable approaches to optimize vaccine responses of older adults who fail to mount a durable response.

引用

页数：4

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