Spinal Mechanisms of Itch Transmission

被引：21

作者：

Barry, Devin M. ^{[1
,2
]}

Munanairi, Admire ^{[1
,2
]}

Chen, Zhou-Feng ^{[1
,2
,3
,4
]}

机构：

[1] Washington Univ, Ctr Study Itch, Sch Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dev Biol, St Louis, MO 63110 USA

来源：

NEUROSCIENCE BULLETIN | 2018年 / 34卷 / 01期

关键词：

Itch; Neuropeptides; Spinal cord; DRG; GPCR signaling; GASTRIN-RELEASING-PEPTIDE; TRIGEMINOTHALAMIC TRACT NEURONS; MAMMALIAN BOMBESIN RECEPTORS; DORSAL-HORN NEURONS; SENSORY NEURONS; NERVOUS-SYSTEM; DESCENDING CONTROL; ATOPIC-DERMATITIS; LEVELS CORRELATE; NEUROMEDIN-B;

D O I：

10.1007/s12264-017-0125-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peripheral itch stimuli are transmitted by sensory neurons to the spinal cord dorsal horn, which then transmits the information to the brain. The molecular and cellular mechanisms within the dorsal horn for itch transmission have only been investigated and identified during the past ten years. This review covers the progress that has been made in identifying the peptide families in sensory neurons and the receptor families in dorsal horn neurons as putative itch transmitters, with a focus on gastrin-releasing peptide (GRP)-GRP receptor signaling. Also discussed are the signaling mechanisms, including opioids, by which various types of itch are transmitted and modulated, as well as the many conflicting results arising from recent studies.

引用

页码：156 / 164

页数：9

共 67 条

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