Label-Free Discrimination of Normal and Fibroadenomal Breast Tissues Using Second Harmonic Generation Imaging

被引：9
|
作者：
Zheng, Liqin [1 ]
Zhuo, Shuangmu [1 ]
Chen, Gang [2 ]
Zhu, Xiaoqin [1 ]
Jiang, Xingshan [1 ]
Yan, Jun [3 ]
Chen, Jianxin [1 ]
Xie, Shusen [1 ]
机构：
[1] Fujian Normal Univ, Inst Laser & Optoelect Technol, Fujian Prov Key Lab Photon Technol, Key Lab OptoElect Sci & Technol Med,Minist Educ, Fuzhou 350007, Peoples R China
[2] Fujian Prov Tumor Hosp, Dept Pathol, Fuzhou 350014, Peoples R China
[3] Fujian Prov Tumor Hosp, Dept Surg, Fuzhou 350014, Peoples R China
来源：
SCANNING | 2011年 / 33卷 / 04期
基金：
中国国家自然科学基金;
关键词：
fibroadenoma; collagen; second-harmonic generation imaging; CANCER; RISK; COLLAGEN; DISEASE; STROMA; WOMEN;
D O I：
10.1002/sca.20234
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Early detection of fibroadenoma (FA) is critical for preventing subsequent breast cancer. In this work, we show that label-free second harmonic generation (SHG) imaging is feasible and effective in quantitatively differentiating the fibroadenomal tissue from normal breast tissue. With the advent of the clinical portability of miniature SHG microscopy, we believe that the technique has great potential in offering a noninvasive in vivo imaging tool for early detection of FA and monitoring the treatment responses of FA in clinics. SCANNING 33: 208-210, 2011. (C) 2011 Wiley Periodicals, Inc.
引用
收藏
页码：208 / 210
页数：3
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