Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

被引：78

作者：

Di Meo, Francesco ^{[1
,2
]}

Valentino, Anna ^{[3
]}

Petillo, Orsolina ^{[4
]}

Peluso, Gianfranco ^{[4
]}

Filosa, Stefania ^{[1
,5
]}

Crispi, Stefania ^{[1
,6
]}

机构：

[1] CNR, UOS Naples, Inst Biosci & BioResources, Via P Castellino 111, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dept Biol, Complesso Univ Monte St Angelo,Via Cinthia, I-80126 Naples, Italy

[3] Elleva Pharma Srl, Via P Castellino 111, I-80131 Naples, Italy

[4] CNR, Inst Terr Ecosyst IRET, Via P Castellino 111, I-80131 Naples, Italy

[5] IRCCS Neuromed, I-86077 Pozzilli, IS, Italy

[6] Stn Zool Anton Dohrn, Villa Comunale, I-80121 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 07期

关键词：

polyphenols; neuroprotection; apoptosis prevention; oxidative stress; gut microbiota; OXIDATIVE STRESS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; SIGNALING PATHWAYS; DNA-DAMAGE; RAT MODEL; ANTIOXIDANT CAPACITY; COGNITIVE IMPAIRMENT; MEMORY IMPAIRMENT; GUT MICROBIOTA;

D O I：

10.3390/ijms21072564

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interest in dietary polyphenols in recent years has greatly increased due to their antioxidant bioactivity with preventive properties against chronic diseases. Polyphenols, by modulating different cellular functions, play an important role in neuroprotection and are able to neutralize the effects of oxidative stress, inflammation, and apoptosis. Interestingly, all these mechanisms are involved in neurodegeneration. Although polyphenols display differences in their effectiveness due to interindividual variability, recent studies indicated that bioactive polyphenols in food and beverages promote health and prevent age-related cognitive decline. Polyphenols have a poor bioavailability and their digestion by gut microbiota produces active metabolites. In fact, dietary bioactive polyphenols need to be modified by microbiota present in the intestine before being absorbed, and to exert health preventive effects by interacting with cellular signalling pathways. This literature review includes an evaluation of the literature in English up to December 2019 in PubMed and Web of Science databases. A total of 307 studies, consisting of research reports, review articles and articles were examined and 146 were included. The review highlights the role of bioactive polyphenols in neurodegeneration, with a particular emphasis on the cellular and molecular mechanisms that are modulated by polyphenols involved in protection from oxidative stress and apoptosis prevention.

引用

页数：21

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