I2/CHP-Mediated Oxidative Coupling of 2-Aminobenzamides and Isocyanides: Access to 2-Aminoquinazolinones

被引：13

作者：

Wei, Tian-Qi

Xu, Pei

Wang, Shun-Yi ^{[1
]}

Ji, Shun-Jun ^{[1
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 32期

基金：

中国国家自然科学基金;

关键词：

Nitrogen heterocycles; Iodine; Isocyanides; Cyclization; Oxidation; Synthetic methods; C-H; PALLADIUM; HETEROCYCLES; INSERTION; DERIVATIVES; AMINATION; CHEMISTRY; AMINES;

D O I：

10.1002/ejoc.201600876

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An oxidative coupling of 2-aminobenzamides 1 and isocyanides 2 mediated by I-2 and cumyl hydroperoxide (CHP) leads to the formation of 2-aminoquinazolinones 3 in moderate to excellent yields. This method provides an efficient approach to 2-aminoquinazolinones with high atom economy under metal-free conditions through two C-N bond-formation reactions. The products can be further transformed to give benzo[4,5]imidazo[2,1-b]quinazolin-12(6H)-one (4).

引用

页码：5393 / 5398

页数：6

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