In Vitro Study: Effect of Cobalt(II) Chloride Against Dengue Virus Type 1 in Vero Cells

被引：1

作者：

Untoro, Yovilianda Maulitiva ^{[1
]}

Sucipto, Teguh Hari ^{[2
]}

Setyawati, Harsasi ^{[1
]}

Maharani, Anisa ^{[1
]}

Sholihah, Novia Faridatus ^{[1
]}

Churrotin, Siti ^{[2
]}

Amarullah, Ilham Harlan ^{[2
]}

Soegijanto, Soegeng ^{[2
]}

机构：

[1] Univ Airlangga, Dept Chem, Fac Sci & Technol, Campus C, Surabaya 60115, Indonesia

[2] Univ Airlangga, Inst Trop Dis, Dengue Study Grp, Surabaya 60115, Indonesia

来源：

INDONESIAN JOURNAL OF PHARMACY | 2019年 / 30卷 / 04期

关键词：

Cobalt(II) chloride; DENV-1; Antiviral activity; CYTOTOXICITY; COPPER(II); COMPLEXES;

D O I：

10.14499/indonesianjpharm30iss4pp316

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dengue virus (DENV) serotypes possess various types from DENV-1 to DENV-4 that are enveloped viruses belong to the genus Flavivirus of the Flaviviridae. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been significant efforts toward this end. Antiviral activity against DENV is needed to develop to be an alternative drug for the DENV virus. Cobalt(II) chloride has been used in the treatment and prevention of diseases of humans since ancient times. This study aimed to investigate the antiviral effects and Cytotoxicity of Cobalt(II) chloride. This compound was further investigated for its inhibitory effect on the replication of DENV-1 in Vero cells. The antiviral activity and cytotoxic was measured by WST-1 assay. The IC50 value of the Cobalt(II) chloride for DENV-1 was 0.38 mu g/ml. The cytotoxicity of Cobalt(II) chloride to Vero cell suggests that the CC50 value was 2.91 mu g/ml. The results of this study demonstrate the anti-dengue serotype 1 inhibitory activity of Cobalt(II) chloride was highly toxic.

引用

页码：316 / 320

页数：5

共 46 条

[21] Evaluation of in vitro antiviral activity of Chelidonium majus L. against herpes simplex virus type-1 [J].

Monavari, Seyed Hamidreza ;

Shahrabadi, Mahmoud Shamsi ;

Keyvani, Hossein ;

Bokharaei-Salim, Farah .

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, 2012, 6 (20) :4360-4364

[22] Antiviral activity of Phoenix dactylifera extracts against herpes simplex virus type 1: an animal study [J].

Allahyari S. ;

Pakbin B. ;

Amani Z. ;

Mahmoudi R. ;

Hamidiyan G. ;

Peymani A. ;

Qajarbeygi P. ;

Mousavi S. .

Comparative Clinical Pathology, 2021, 30 (6) :945-951

[23] In vitro evaluation of antiviral activity of Shouchella clausii probiotic strain and bacterial supernatant against herpes simplex virus type 1 [J].

Barzoki, Mehdi Gholami ;

Malekshahi, Somayeh Shatizadeh ;

Shayestehpour, Mohammad .

ARCHIVES OF MICROBIOLOGY, 2022, 204 (08)

[24] In vitro evaluation of antiviral activity of Shouchella clausii probiotic strain and bacterial supernatant against herpes simplex virus type 1 [J].

Mehdi Gholami barzoki ;

Somayeh Shatizadeh Malekshahi ;

Mohammad Shayestehpour .

Archives of Microbiology, 2022, 204

[25] Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro [J].

Pei, Ying ;

Chen, Zhen-Ping ;

Ju, Huai-Qiang ;

Komatsu, Masaaki ;

Ji, Yu-hua ;

Liu, Ge ;

Guo, Chao-wan ;

Zhang, Ying-Jun ;

Yang, Chong-Ren ;

Wang, Yi-Fei ;

Kitazato, Kaio .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 405 (02) :186-191

[26] In vitro Anti-viral Activity of the Total Alkaloids from Tripterygium hypoglaucum against Herpes Simplex Virus Type 1 [J].

Zhe REN1 ;

2. Medical College of Jinan University ;

3. National Engineering Research Center of Genetic Medicine ;

4. Department of Chemistry and Biology ;

5. Kunming Institute of Botany ;

6. South China Botanical Garden .

Virologica Sinica, 2010, 25 (02) :107-114

[27] Image mean square displacement to study the lateral mobility of Angiotensin II type 1 and Endothelin 1 type A receptors on living cells [J].

Planes, Nadir ;

Vanderheyden, Patrick P. M. L. ;

Gratton, Enrico ;

Caballero-George, Catherina .

MICROSCOPY RESEARCH AND TECHNIQUE, 2020, 83 (04) :381-392

[28] Combined cytotoxic activity of an infectious, but non-replicative herpes simplex virus type 1 and plasmacytoid dendritic cells against tumour cells [J].

Thomann, Sabrina ;

Boscheinen, Jan B. ;

Vogel, Karin ;

Knipe, David M. ;

DeLuca, Neal ;

Gross, Stefanie ;

Schuler-Thurner, Beatrice ;

Schuster, Philipp ;

Schmidt, Barbara .

IMMUNOLOGY, 2015, 146 (02) :327-338

[29] Inhibitory effect of Spirogyra spp. algal extracts against herpes simplex virus type 1 and 2 infection [J].

Deethae, A. ;

Peerapornpisal, Y. ;

Pekkoh, J. ;

Sangthong, P. ;

Tragoolpua, Y. .

JOURNAL OF APPLIED MICROBIOLOGY, 2018, 124 (06) :1441-1453

[30] Effect of PR toxin on THP1 and Caco-2 cells: an in vitro study [J].

Hymery, N. ;

Puel, O. ;

Tadrist, S. ;

Canlet, C. ;

Le Scouarnec, H. ;

Coton, E. ;

Coton, M. .

WORLD MYCOTOXIN JOURNAL, 2017, 10 (04) :375-386

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