In Vitro Study: Effect of Cobalt(II) Chloride Against Dengue Virus Type 1 in Vero Cells

被引：1

作者：

Untoro, Yovilianda Maulitiva ^{[1
]}

Sucipto, Teguh Hari ^{[2
]}

Setyawati, Harsasi ^{[1
]}

Maharani, Anisa ^{[1
]}

Sholihah, Novia Faridatus ^{[1
]}

Churrotin, Siti ^{[2
]}

Amarullah, Ilham Harlan ^{[2
]}

Soegijanto, Soegeng ^{[2
]}

机构：

[1] Univ Airlangga, Dept Chem, Fac Sci & Technol, Campus C, Surabaya 60115, Indonesia

[2] Univ Airlangga, Inst Trop Dis, Dengue Study Grp, Surabaya 60115, Indonesia

来源：

INDONESIAN JOURNAL OF PHARMACY | 2019年 / 30卷 / 04期

关键词：

Cobalt(II) chloride; DENV-1; Antiviral activity; CYTOTOXICITY; COPPER(II); COMPLEXES;

D O I：

10.14499/indonesianjpharm30iss4pp316

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dengue virus (DENV) serotypes possess various types from DENV-1 to DENV-4 that are enveloped viruses belong to the genus Flavivirus of the Flaviviridae. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been significant efforts toward this end. Antiviral activity against DENV is needed to develop to be an alternative drug for the DENV virus. Cobalt(II) chloride has been used in the treatment and prevention of diseases of humans since ancient times. This study aimed to investigate the antiviral effects and Cytotoxicity of Cobalt(II) chloride. This compound was further investigated for its inhibitory effect on the replication of DENV-1 in Vero cells. The antiviral activity and cytotoxic was measured by WST-1 assay. The IC50 value of the Cobalt(II) chloride for DENV-1 was 0.38 mu g/ml. The cytotoxicity of Cobalt(II) chloride to Vero cell suggests that the CC50 value was 2.91 mu g/ml. The results of this study demonstrate the anti-dengue serotype 1 inhibitory activity of Cobalt(II) chloride was highly toxic.

引用

页码：316 / 320

页数：5

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