Reversible dementia in a patient with central nervous system escape of human immunodeficiency virus

被引：27

作者：

Bogoch, Isaac I. ^{[1
,3
]}

Davis, Benjamin T. ^{[1
,3
]}

Venna, Nagagopal ^{[2
,3
]}

机构：

[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Div Neurol, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA USA

来源：

JOURNAL OF INFECTION | 2011年 / 63卷 / 03期

关键词：

HIV; AIDS; Dementia; ANTIRETROVIRAL THERAPY; HIV; FLUID;

D O I：

10.1016/j.jinf.2011.05.011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

HIV-associated neurocognitive disorders (HAND) are a group of conditions ranging from asymptomatic neurocognitive impairment to disabling dementia. The clinical spectrum and pathogenesis of these disorders is changing in the era of highly active antiretroviral therapy (HAART). High levels of HIV may exist in the cerebrospinal fluid (CSF) of some patients despite suppression of serum viral loads by HAART. We report a case of a 51-year-old male with profound levels of HIV in the CSF despite low serum levels. Adjusting his HAART regimen based on HIV genotype susceptibility data and a CNS Penetrating Effectiveness (CPE) score resulted in a dramatic improvement in cognitive function. Progressive dementia in this context is a rare but emerging trend and may be reversible. (C) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：236 / 239

页数：4

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