The prefrontal-limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrain

被引：69
作者：
Bennett, M. R. [1 ]
机构：
[1] Univ Sydney, Brain & Mind Res Inst, Camperdown, NSW 2050, Australia
来源：
PROGRESS IN NEUROBIOLOGY | 2011年 / 93卷 / 04期
关键词：
Depression; Cingulate cortex; Hippocampus; Amygdala; Hypothalamus; Basal ganglia; WHITE-MATTER HYPERINTENSITIES; GLUCOCORTICOID-RECEPTOR GENE; MRI SIGNAL HYPERINTENSITIES; PITUITARY-ADRENAL RESPONSES; INCREASES DOPAMINE RELEASE; LONG-TERM POTENTIATION; ORBITOFRONTAL CORTEX; NEUROTROPHIC FACTOR; SUICIDAL-BEHAVIOR; MATERNAL-CARE;
D O I：
10.1016/j.pneurobio.2011.01.006
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The anterior cingulate cortex, amygdala and hippocampus form part of an interconnected prefrontal neocortical and limbic archicortical network that is dysregulated in major depressive disorders (MDD). Modulation of this prefrontal-limbic network (PLN) is principally through the hypothalamus, basal ganglia and midbrain. Here the likely mechanisms by which these modulations are affected are described and the implications of their failure for depression associated with suicidal diathesis, late-life and psychoses discussed. (C) 2011 Elsevier Ltd. All rights reserved.
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收藏
页码：468 / 487
页数：20
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