Changes in metabolism of collagen in genitourinary

被引：289

作者：

Jackson, SR ^{[1
]}

Avery, NC ^{[1
]}

Tarlton, JF ^{[1
]}

Echford, SD ^{[1
]}

Abrams, P ^{[1
]}

Bailey, AJ ^{[1
]}

机构：

[1] UNIV BRISTOL, COLLLAGEN RES GRP, BRISTOL, AVON, ENGLAND

来源：

LANCET | 1996年 / 347卷 / 9016期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0140-6736(96)91489-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Genitourinary prolapse is a common problem, the pathophysiology of which is unknown. Methods We analysed vaginal-epithelial tissue from premenopausal women with genitourinary prolapse and compared them with controls. Findings We found that genitourinary prolapse is associated with a reduction in total collagen content and a decrease in collagen solubility. Both intermediate intermolecular cross-links acid advanced glycation crosslinks were increased in prolapse tissue. Collagen turnover, as indicated by matrix metalloproteinase activity, was up to four times higher in prolapse tissue. Collagen-type ratios, mature cross-link pyridinoline and total elastin content were similar in both prolapse and control tissues. Increased collagenolytic activity causes loss of collagen from prolapse tissue. Interpretation Based on these findings, we have identified a probable mechanism for genitourinary prolapse. Development of agents to inhibit collagenolytic activity may help in the treatment of this condition.

引用

页码：1658 / 1661

页数：4

共 17 条

[1] MATRIX METALLOPROTEINASE-2 IS AN INTERSTITIAL COLLAGENASE - INHIBITOR-FREE ENZYME CATALYZES THE CLEAVAGE OF COLLAGEN FIBRILS AND SOLUBLE NATIVE TYPE-I COLLAGEN GENERATING THE SPECIFIC 3/4-LENGTH AND 1/4-LENGTH FRAGMENTS [J].

AIMES, RT ;

QUIGLEY, JP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (11) :5872-5876

[2] NONENZYMATIC GLYCATION OF FIBROUS COLLAGEN - REACTION-PRODUCTS OF GLUCOSE AND RIBOSE [J].

BAILEY, AJ ;

SIMS, TJ ;

AVERY, NC ;

HALLIGAN, EP .

BIOCHEMICAL JOURNAL, 1995, 305 :385-390

[3] THE CONTINUOUS ELONGATION TECHNIQUE FOR SEVERE DUPUYTRENS DISEASE - A BIOCHEMICAL-MECHANISM [J].

BAILEY, AJ ;

TARLTON, JF ;

VANDERSTAPPEN, J ;

SIMS, TJ ;

MESSINA, A .

JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME, 1994, 19B (04) :522-527

[4] ADAPTATION OF BERGMAN AND LOXLEY TECHNIQUE FOR HYDROXYPROLINE DETERMINATION TO AUTOANALYZER AND ITS USE IN DETERMINING PLASMA HYDROXYPROLINE IN DOMESTIC FOWL [J].

BANNISTER, DW ;

BURNES, AB .

ANALYST, 1970, 95 (1131) :596-+

[5] SEX-HORMONES AND SKIN COLLAGEN CONTENT IN POST-MENOPAUSAL WOMEN [J].

BRINCAT, M ;

MONIZ, CF ;

STUDD, JWW ;

DARBY, AJ ;

MAGOS, A ;

COOPER, D .

BRITISH MEDICAL JOURNAL, 1983, 287 (6402) :1337-1338

[6]

el-Kholi G Y, 1975, J Egypt Med Assoc, V58, P196

[7]

KEANE DP, 1992, NEUROUROL URODYNAM, V11, P308

[8] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[9] ESTIMATION OF TYPE-I AND TYPE-III COLLAGENS IN WHOLE TISSUE BY QUANTITATION OF CNBR PEPTIDES ON SDS-POLYACRYLAMIDE GELS [J].

LIGHT, ND .

BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 702 (01) :30-36

[10]

LIGHT ND, 1982, STRUCTURAL CONTRACTI

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