Highly Efficient Synthesis of Chiral α-CF3 Amines via Rh-Catalyzed Asymmetric Hydrogenation

被引：32

作者：

Jiang, Jun

Lu, Wenxin

Lv, Hui ^{[1
]}

Zhang, Xumu

机构：

[1] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE HYDROGENATION; TRIFLUOROMETHYLATED AMINES; PHOSPHORUS LIGANDS; FLUORINE;

D O I：

10.1021/acs.orglett.5b00087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly enantioselective catalytic asymmetric hydrogenation of alpha-CF3-enamides has been achieved by employing rhodium-DuanPhos as the catalyst, which provides a readily accessible method for the synthesis of chiral trifluoromethylated amines. The reaction has a broad substrate scope; both aryl- and alkyl-substituted alpha-CF3-enamides worked smoothly and afford the corresponding chiral amines in high yields and excellent enantioselectivities (up to 99% ee).

引用

收藏

页码：1154 / 1156

页数：3

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