Thermodynamic and analytical studies of drugs binary systems of paracetamol mixed with pseudoephedrine.HCl, dextropropoxyphene.HCl and tramadol.HCl

被引：8
作者：
Boumrah, Yacine [1 ,2 ]
Bouzahia, Imane [2 ]
Bouanani, Sabrina [2 ]
Khimeche, Kamel [3 ]
Dahmani, Abdallah [1 ]
机构：
[1] USTHB, Fac Chim, Lab Thermodynam & Modelisat Mol, BP 32 El Alia, Bab Ezzouar 16111, Alger, Algeria
[2] Inst Natl Criminalist & Criminol INCC GN, Bouchaoui, Alger, Algeria
[3] EMP, BP 17 Bordj El Bahri, Algiers, Algeria
来源：
THERMOCHIMICA ACTA | 2016年 / 634卷
关键词：
DSC; HPTLC; Pseudoephedrine; Dextropropoxyphene; Tramadol; Paracetamol; DIFFERENTIAL SCANNING CALORIMETRY; RESPIRATORY-TRACT INFECTION; SOLID-LIQUID EQUILIBRIA; DOUBLE-BLIND; EUTECTIC FORMATION; PHASE-EQUILIBRIA; NASAL CONGESTION; THERMAL-ANALYSIS; DOSAGE FORMS; COMMON COLD;
D O I：
10.1016/j.tca.2016.03.025
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
In this paper, we report a DSC investigation of solid-liquid equilibria in three binary mixtures of paracetamol, namely with pseudoephedrine, dextropropoxyphene and tramadol, resulting in a temperature-composition phase diagrams with eutectic equilibrium. Eutectic mole fractions, temperatures and enthalpies were determined and reported for each system. The study reports also a direct exploitation of the DSC results for the quantification purpose, which were in good agreement with those obtained by a standard analytical method namely high performance thin layer chromatography (HPTLC), used in this work for comparison purpose. (C) 2016 Published by Elsevier B.V.
引用
收藏
页码：48 / 56
页数：9
相关论文
共 52 条
[1]   Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: A multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging study [J].
Bachert, C ;
Chuchalin, AG ;
Eisebitt, R ;
Netayzhenko, VZ ;
Voelker, M .
CLINICAL THERAPEUTICS, 2005, 27 (07) :993-1003
[2]   A DSC COMPOSITIONAL ANALYSIS OF SOME BINARY ORGANIC MIXTURES OF PHARMACEUTICAL SIGNIFICANCE [J].
BECKET, G ;
QUAH, SB ;
HILL, JO .
JOURNAL OF THERMAL ANALYSIS, 1993, 40 (02) :537-542
[3]   Mechanism of eutectic formation upon compaction and its effects on tablet properties [J].
Bi, MD ;
Hwang, SJ ;
Morris, KR .
THERMOCHIMICA ACTA, 2003, 404 (1-2) :213-226
[4]   DSC and adiabatic calorimetry study of the polymorphs of paracetamol - An old problem revisited [J].
Boldyreva, EV ;
Drebushchak, VA ;
Paukov, IE ;
Kovalevskaya, YA ;
Drebushchak, TN .
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2004, 77 (02) :607-623
[5]   Analysis of synthetic drugs by differential scanning calorimetry Case of amphetamine-type stimulants (ATS) [J].
Boumrah, Yacine ;
Bouanani, Sabrina ;
Khimeche, Kamel ;
Dahmani, Abdellah .
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2015, 120 (01) :583-590
[6]   Single-dose dextropropoxyphene in post-operative pain: a quantitative systematic review [J].
Collins, SL ;
Edwards, JE ;
Moore, RA ;
McQuay, HJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 54 (02) :107-112
[7]   THERMAL ANALYTICAL TECHNIQUES APPLIED TO THE NARCOTIC FIELD - COCAINE ANALYSIS [J].
CURINI, R ;
ZAMPONI, S ;
DASCENZO, F ;
CURTIS, SD ;
MARINO, A ;
DEZZI, A .
THERMOCHIMICA ACTA, 1989, 153 :11-26
[8]   Tramadol/Paracetamol Fixed-Dose Combination A Review of its Use in the Management of Moderate to Severe Pain [J].
Dhillon, Sohita .
CLINICAL DRUG INVESTIGATION, 2010, 30 (10) :711-738
[9]   Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection [J].
Eccles, R. ;
Jawad, M. ;
Jawad, S. ;
Ridge, D. ;
North, M. ;
Jones, E. ;
Burnett, I. .
CURRENT MEDICAL RESEARCH AND OPINION, 2006, 22 (12) :2411-2418
[10]   Efficacy and safety of single and multiple doses of pseudoephedrine in the treatment of nasal congestion associated with common cold [J].
Eccles, R ;
Jawad, MSM ;
Jawad, SSM ;
Angello, JT ;
Druce, HM .
AMERICAN JOURNAL OF RHINOLOGY, 2005, 19 (01) :25-31
123456