Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata

被引：36

作者：

Ikeda, Y

Nonaka, H

Furumai, T

Igarashi, Y

机构：

[1] Mitsubishi Pharma Corp, Pharmaceut Res Unit, Hirakata, Osaka 5731153, Japan

[2] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 04期

关键词：

D O I：

10.1021/np049650x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K-i value of 126 nM.

引用

页码：572 / 573

页数：2

共 10 条

[1]

CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099

[2]

GOODMAN, 1985, PHARM BASIS THERAPEU, P130

[3] KERAMAMIDE-E, KERAMAMIDE-G, KERAMAMIDE-H AND KERAMAMIDE-J, NEW CYCLIC-PEPTIDES CONTAINING AN OXAZOLE OR A THIAZOLE RING FROM A THEONELLA SPONGE [J].