14D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate

被引：334

作者：

Miao, Shida ^{[1
]}

Zhu, Wei ^{[1
]}

Castro, Nathan J. ^{[1
]}

Nowicki, Margaret ^{[1
]}

Zhou, Xuan ^{[1
]}

Cui, Haitao ^{[1
]}

Fisher, John P. ^{[2
]}

Zhang, Lijie Grace ^{[1
,3
,4
]}

机构：

[1] George Washington Univ, Dept Mech & Aerosp Engn, Washington, DC 20052 USA

[2] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA

[3] George Washington Univ, Dept Biomed Engn, Washington, DC 20052 USA

[4] George Washington Univ, Dept Med, Washington, DC 20052 USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

美国国家科学基金会;

关键词：

VEGETABLE-OIL; POLYURETHANE NETWORKS; STEREOLITHOGRAPHY; BIOMATERIALS; HYDROGELS;

D O I：

10.1038/srep27226

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Photocurable, biocompatible liquid resins are highly desired for 3D stereolithography based bioprinting. Here we solidified a novel renewable soybean oil epoxidized acrylate, using a 3D laser printing technique, into smart and highly biocompatible scaffolds capable of supporting growth of multipotent human bone marrow mesenchymal stem cells (hMSCs). Porous scaffolds were readily fabricated by simply adjusting the printer infill density; superficial structures of the polymerized soybean oil epoxidized acrylate were significantly affected by laser frequency and printing speed. Shape memory tests confirmed that the scaffold fixed a temporary shape at -18 degrees C and fully recovered its original shape at human body temperature (37 degrees C), which indicated the great potential for 4D printing applications. Cytotoxicity analysis proved that the printed scaffolds had significant higher hMSC adhesion and proliferation than traditional polyethylene glycol diacrylate (PEGDA), and had no statistical difference from poly lactic acid (PLA) and polycaprolactone (PCL). This research is believed to significantly advance the development of biomedical scaffolds with renewable plant oils and advanced 3D fabrication techniques.

引用

页数：10

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