Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes

被引:13
|
作者
Otsuka, Kunihiro [1 ]
Yamada, Koichi [1 ]
Taquahashi, Yuhji [2 ]
Arakaki, Rieko [1 ]
Ushio, Aya [1 ]
Saito, Masako [3 ]
Yamada, Akiko [1 ]
Tsunematsu, Takaaki [4 ]
Kudo, Yasusei [1 ]
Kanno, Jun [5 ]
Ishimaru, Naozumi [1 ]
机构
[1] Tokushima Univ, Dept Oral Mol Pathol, Grad Sch Biomed Sci, Tokushima, Japan
[2] Natl Inst Hlth Sci, Biol Safety Res Ctr, Div Cellular & Mol Toxicol, Kanagawa, Japan
[3] Tokushima Univ, Dept Immunol & Parasitol, Grad Sch Biomed Sci, Tokushima, Japan
[4] Tokushima Univ, Dept Pathol & Lab Med, Grad Sch Biomed Sci, Tokushima, Japan
[5] Japan Org Occupat Hlth & Safety, Japan Bioassay Res Ctr, Kanagawa, Japan
来源
PLOS ONE | 2018年 / 13卷 / 10期
关键词
PULMONARY INFLAMMATION; OXIDATIVE STRESS; TISSUE-REPAIR; LUNG FIBROSIS; MICE; NANOPARTICLES; TOXICITY; RESPONSES; MECHANISMS; DEFICIENT;
D O I
10.1371/journal.pone.0205702
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Nanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear. Methods and finding In this study, exposure to Taquann-treated multi-walled CNTs (T-CNTs) was performed using aerosols generated in an inhalation chamber. At 12 months after T-CNT exposure, alveolar inflammation with macrophage accumulation and hypertrophy of the alveolar walls were observed. In addition, fibrotic lesions were enhanced by T-CNT exposure. The macrophages in the bronchoalveolar lavage fluid of T-CNT-exposed mice were not largely shifted to any particular population, and were a mixed phenotype with M1 and M2 polarization. Moreover, the alveolar macrophages of T-CNT-exposed mice produced matrix metalloprotinase-12. Conclusions These results suggest that T-CNT exposure promoted chronic inflammation and fibrotic lesion formation in profibrotic macrophages for prolonged periods.
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页数:18
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