The nonhemostatic immune functions of platelets

被引：24
作者：
Kapur, Rick [1 ]
Semple, John W. [1 ,2 ,3 ,4 ]
机构：
[1] St Michaels Hosp, Canadian Blood Serv, Keenan Res Ctr Biomed Sci, Toronto Platelet Immunobiol Grp, Toronto, ON, Canada
[2] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada
[3] Univ Toronto, Dept Med, Toronto, ON, Canada
[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
来源：
SEMINARS IN HEMATOLOGY | 2016年 / 53卷 / 02期
关键词：
Platelets; Inflammation; Immunity; Infections; Chemokines; Cytokines; IDIOPATHIC THROMBOCYTOPENIC PURPURA; ACTIVATED HUMAN PLATELETS; MHC CLASS-I; MOLECULAR MIMICRY; MESSENGER-RNA; IMMUNOLOGICAL THROMBOCYTOPENIA; CARDIOVASCULAR-DISEASE; ENDOTHELIAL-CELLS; ALPHA-GRANULES; EMERGING ROLE;
D O I：
10.1053/j.seminhematol.2016.04.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Platelets are megakaryocyte-derived cellular fragments, which lack a nucleus and are the smallest circulating cells and are classically known to have a major role in supporting hemostasis. Apart from this well-established role, it is now becoming evident that platelets are also capable of conveying other important functions, such as during infection and inflammation. This paper will outline these non hemostatic functions in two major sections termed "Platelets versus pathogens" and "Platelet-target cell communication". Platelets actively contribute to protection against invading pathogens and are capable of regulating immune functions in various target cells, all through sophisticated and efficient mechanisms. These relatively novel features will be highlighted, illustrating the multifunctional role of platelets in inflammation. (C) 2016 Elsevier Inc. All rights reserved.
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收藏
页码：S2 / S6
页数：5
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