Oxidation and flow-injection amperometric determination of 5-hydroxytryptophan at an electrode modified by electrochemically assisted deposition of a sol-gel film with templated nanoscale pores

被引：19
作者：
Ranganathan, David [1 ,2 ]
Zamponi, Silvia [2 ]
Berrettoni, Mario [3 ,4 ]
Mehdi, B. Layla [1 ]
Cox, James A. [1 ]
机构：
[1] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA
[2] Univ Camerino, Dept Chem Sci, I-62032 Camerino, Italy
[3] Univ Bologna, Dept Phys & Inorgan Chem, I-40136 Bologna, Italy
[4] INSTM Bologna, Unita Ric, I-40136 Bologna, Italy
来源：
TALANTA | 2010年 / 82卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Sol-gel films; Electrochemically assisted deposition; 5-Hydroxytryptophan; Voltammetry; Flow-injection analysis; MODIFIED GLASSY-CARBON; COBALT HEXACYANOFERRATE; ELECTROCATALYTIC OXIDATION; SILICA MICROSPHERES; HYDROLYSIS; DENDRIMERS; SURFACES; ANILINE;
D O I：
10.1016/j.talanta.2010.06.025
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The oxidation of 5-hydroxytryptophan (5-HTPP) yielded a passivating polymeric film at an indium tin oxide (ITO) electrode. Coating ITO with a nanoscale sol-gel film with a mesoporous structure was shown to change the pathway of the chemical reaction coupled to the electron transfer. The sol-gel film was deposited by an electrochemically assisted process, and the mesoporosity was imparted by including generation-4 poly(amidoamine) dendrimer in the precursor solution. The dendrimer was removed subsequently with an atmospheric oxygen plasma. This electrode remained active during cyclic voltammetry and controlled potential electrolysis of 5-HTPP, which was attributed to dimer, rather than polymer, formation from the oxidation product. Mass spectrometry confirmed this hypothesis. The anodic current was limited by the electron-transfer kinetics. Modification of the so-gel film by inclusion of cobalt hexacyanoferrate, which catalyzes the oxidation, resulted in a diffusion-limited current. Determination of 5-HTPP by flow-injection amperometry had a detection limit of 17 nM. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：1149 / 1155
页数：7
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