Neuronal Development in Caenorhabditis elegans Is Regulated by Inhibition of an MLK MAP Kinase Pathway

被引：12

作者：

Baker, Scott T. ^{[1
,2
]}

Turgeon, Shane M. ^{[1
]}

Tulgren, Erik D. ^{[2
]}

Wigant, Jeanne ^{[2
]}

Rahimi, Omeed ^{[2
]}

Opperman, Karla J. ^{[1
]}

Grill, Brock ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Neurosci, Jupiter, FL 33458 USA

[2] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

GENETICS | 2015年 / 199卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

AXON REGENERATION REQUIRES; SYNAPSE FORMATION; C-ELEGANS; TERMINATION; RPM-1; SYNAPTOGENESIS; DLK-1; P38;

D O I：

10.1534/genetics.114.170589

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We show that loss-of-function mutations in kinases of the MLK-1 pathway (mlk-1, mek-1, and kgb-1/jnk) function cell-autonomously in neurons to suppress defects in synapse formation and axon termination caused by rpm-1 loss of function. Our genetic analysis also suggests that the phosphatase PPM-1, like RPM-1, is a potential inhibitor of kinases in the MLK-1 pathway.

引用

页码：151 / U582

页数：8

共 15 条

[1] RPM-1 Uses Both Ubiquitin Ligase and Phosphatase-Based Mechanisms to Regulate DLK-1 during Neuronal Development [J].

Baker, Scott T. ;

Opperman, Karla J. ;

Tulgren, Erik D. ;

Turgeon, Shane M. ;

Bienvenut, Willy ;

Grill, Brock .

PLOS GENETICS, 2014, 10 (05)

[2] Highwire restrains synaptic growth by attenuating a MAP kinase signal [J].

Collins, Catherine A. ;

Wairkar, Yogesh P. ;

Johnson, Sylvia L. ;

DiAntonio, Aaron .

NEURON, 2006, 51 (01) :57-69

[3] C-elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1 [J].

Grill, Brock ;

Bienvenut, Willy V. ;

Brown, Heather M. ;

Ackley, Brian D. ;

Quadroni, Manfredo ;

Jin, Yishi .

NEURON, 2007, 55 (04) :587-601

[4] RAE-1, a Novel PHR Binding Protein, Is Required for Axon Termination and Synapse Formation in Caenorhabditis elegans [J].

Grill, Brock ;

Chen, Lizhen ;

Tulgren, Erik D. ;

Baker, Scott T. ;

Bienvenut, Willy ;

Anderson, Matthew ;

Quadroni, Manfredo ;

Jin, Yishi ;

Garner, Craig C. .

JOURNAL OF NEUROSCIENCE, 2012, 32 (08) :2628-2636

[5] Axon Regeneration Requires a Conserved MAP Kinase Pathway [J].

Hammarlund, Marc ;

Nix, Paola ;

Hauth, Linda ;

Jorgensen, Erik M. ;

Bastiani, Michael .

SCIENCE, 2009, 323 (5915) :802-806

[6] JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis [J].

Huntwork-Rodriguez, Sarah ;

Wang, Bei ;

Watkins, Trent ;

Ghosh, Arundhati Sengupta ;

Pozniak, Christine D. ;

Bustos, Daisy ;

Newton, Kim ;

Kirkpatrick, Donald S. ;

Lewcock, Joseph W. .

JOURNAL OF CELL BIOLOGY, 2013, 202 (05) :747-763

[7] Independent Pathways Downstream of the Wnd/DLK MAPKKK Regulate Synaptic Structure, Axonal Transport, and Injury Signaling [J].

Klinedinst, Susan ;

Wang, Xin ;

Xiong, Xin ;

Haenfler, Jill M. ;

Collins, Catherine A. .

JOURNAL OF NEUROSCIENCE, 2013, 33 (31) :12764-12778

[8] The ubiquitin ligase phr1 regulates axon outgrowth through modulation of microtubule dynamics [J].

Lewcock, Joseph W. ;

Genoud, Nicolas ;

Lettieri, Karen ;

Pfaff, Samuel L. .

NEURON, 2007, 56 (04) :604-620

[9] An SCF-like ubiquitin ligase complex that controls presynaptic differentiation [J].

Liao, EH ;

Hung, W ;

Abrams, B ;

Zhen, M .

NATURE, 2004, 430 (6997) :345-350

[10] Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development [J].

Nakata, K ;

Abrams, B ;

Grill, B ;

Goncharov, A ;

Huang, X ;

Chisholm, AD ;

Jin, YS .

CELL, 2005, 120 (03) :407-420

← 1 2 →