Assessment of Coronary Artery Disease Using Magnetic Resonance Coronary Angiography A National Multicenter Trial

被引：188

作者：

Kato, Shingo ^{[1
]}

Kitagawa, Kakuya ^{[1
]}

Ishida, Nanaka ^{[1
]}

Ishida, Masaki ^{[1
]}

Nagata, Motonori ^{[1
]}

Ichikawa, Yasutaka ^{[2
]}

Katahira, Kazuhiro ^{[3
]}

Matsumoto, Yuji ^{[4
]}

Seo, Koji ^{[5
]}

Ochiai, Reiji ^{[6
]}

Kobayashi, Yasuyuki ^{[7
]}

Sakuma, Hajime ^{[1
]}

机构：

[1] Mie Univ Hosp, Dept Radiol, Tsu, Mie 5148507, Japan

[2] Matsusaka Cent Hosp, Dept Radiol, Matsusaka, Japan

[3] Kumamoto City Hosp, Dept Radiol, Kumamoto, Japan

[4] Saijyo Cent Hosp, Dept Cardiol, Saijyo, Japan

[5] Utsunomiya Cent Clin, Dept Cardiol, Utsunomiya, Tochigi, Japan

[6] Koga Hosp, Dept Radiol, Kurume, Fukuoka, Japan

[7] St Marianna Hosp, Dept Radiol, Kawasaki, Kanagawa, Japan

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2010年 / 56卷 / 12期

关键词：

coronary artery; coronary artery disease; magnetic resonance angiography; national multicenter trial; DIAGNOSTIC PERFORMANCE; MR-ANGIOGRAPHY; COMPUTED-TOMOGRAPHY; STENOSIS; STATE; ACCURACY; MINUTES;

D O I：

10.1016/j.jacc.2010.01.071

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives This national multicenter study determined the diagnostic performance of 1.5-T whole-heart coronary magnetic resonance angiography (MRA) in patients with suspected coronary artery disease (CAD). Background Whole-heart coronary MRA using steady-state free precession allows noninvasive detection of CAD without the administration of contrast medium. However, the accuracy of this approach has not been determined in a multicenter trial. Methods Using a 1.5-T magnetic resonance imaging unit, free-breathing steady-state free precession whole-heart coronary MRA images were acquired for 138 patients with suspected CAD at 7 hospitals. The accuracy of MRA for detecting a >= 50% reduction in diameter was determined using X-ray coronary angiography as the reference method. Results Acquisition of whole-heart coronary MRA images was performed in 127 (92%) of 138 patients with an average imaging time of 9.5 +/- 3.5 min. The areas under the receiver-operator characteristic curve from MRA images according to vessel-and patient-based analyses were 0.91 (95% confidence interval [CI]: 0.87 to 0.95) and 0.87 (95% CI: 0.81 to 0.93), respectively. The sensitivity, specificity, positive and negative predictive values, and accuracy of MRA according to a patient-based analysis were 88% (49 of 56, 95% CI: 75% to 94%), 72% (51 of 71, 95% CI: 60% to 82%), 71% (49 of 69, 95% CI: 59% to 81%), 88% (51 of 58, 95% CI: 76% to 95%), and 79% (100 of 127, 95% CI: 72% to 86%), respectively. Conclusions Non-contrast-enhanced whole-heart coronary MRA at 1.5-T can noninvasively detect significant CAD with high sensitivity and moderate specificity. A negative predictive value of 88% indicates that whole-heart coronary MRA can rule out CAD. (J Am Coll Cardiol 2010; 56: 983-91) c 2010 by the American College of Cardiology Foundation

引用

页码：983 / 991

页数：9

共 20 条

[1] Whole-heart coronary magnetic resonance angiography at 3 Tesla in 5 minutes with slow infusion of Gd-BOPTA, a high-relaxivity clinical contrast agent [J].