IFNγ signaling integrity in colorectal cancer immunity and immunotherapy

被引：83

作者：

Du, Wan ^{[1
,2
]}

Frankel, Timothy L. ^{[1
]}

Green, Michael ^{[2
,3
,4
,5
]}

Zou, Weiping ^{[1
,2
,5
,6
,7
]}

机构：

[1] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Ctr Excellence Canc Immunol & Immunotherapy, Rogel Canc Ctr, Sch Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Radiat Oncol, Sch Med, Ann Arbor, MI USA

[4] Univ Michigan, Vet Affairs Ann Arbor Healthcare Syst, Sch Med, Ann Arbor, MI USA

[5] Univ Michigan, Grad Programs Immunol, Sch Med, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Tumor Biol, Sch Med, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2022年 / 19卷 / 01期

关键词：

IFNGR; Interferon; MHC; Palmitoylation; T cell; EZH2; ARID1A; PD-1; PD-L1; Apoptosis; Ferroptosis; Colorectal cancer; Immunity; REGULATORY T-CELLS; INNATE LYMPHOID-CELLS; INTERFERON-GAMMA; TUMOR-IMMUNITY; PD-1; BLOCKADE; CHECKPOINT BLOCKADE; CUTTING EDGE; RESISTANCE; PATHWAY; APOPTOSIS;

D O I：

10.1038/s41423-021-00735-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFN gamma) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFN gamma signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB. Moreover, we discuss how to target IFN gamma signaling to inform novel clinical trials to treat patients with colorectal cancer.

引用

页码：23 / 32

页数：10

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