MULTICOMPONENT, ONE-POT SYNTHESIS OF HIGHLY SUBSTITUTED PYRIDINES WITH ZINC OXIDE NANOPARTICLES AS CATALYST

被引:0
作者
Patil, Kiran [1 ,3 ]
Kumbhar, Deepak [2 ]
Patil, Amol [2 ]
Karhale, Shrikrishna [2 ]
Helavi, Vasant [3 ]
机构
[1] Dr Ghali Coll, Dept Chem, Gadhinglaj, Maharashtra, India
[2] Shivaji Univ, Dept Chem, Kolhapur, Maharashtra, India
[3] Rajaram Coll, Dept Chem, Kolhapur, Maharashtra, India
关键词
ZnO Nanoparticles; Microwave irradiation; Multicomponent reaction; Pyridine derivatives; GREEN SYNTHESIS; ZNO NANOPARTICLES; EFFICIENT; DERIVATIVES; MCR;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
ZnO nanoparticles were used for a highly efficient one-pot synthesis of highly substituted pyridines by the three component condensation reaction of aromatic aldehydes, malononitrile, and ammonium acetate in the mixture of methanol and water as solvent under classical heating. Using microwave heating, reaction times were shortened from 3 hr to 3 min. The advantage of this method includes the use of green catalyst, short reaction time, easy work up, and excellent yields. [GRAPHICS]
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页码:157 / 164
页数:8
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共 32 条
[1]   Nano-ZnO: an efficient and reusable catalyst for one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and pyrazolo[1,2-a][1,2,4]triazole-1,3-diones [J].
Azarifar, Ali ;
Nejat-Yami, Razieh ;
Azarifar, Davood .
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2013, 10 (02) :297-306
[2]   One-step, three-component synthesis of highly substituted pyridines using silica nanoparticle as reusable catalyst [J].
Banerjee, Subhash ;
Sereda, Grigoriy .
TETRAHEDRON LETTERS, 2009, 50 (50) :6959-6962
[3]   Exploring Catalyst and Solvent Effects in the Multicomponent Synthesis of Pyridine-3,5-dicarbonitriles [J].
Guo, Kai ;
Thompson, Mark J. ;
Chen, Beining .
JOURNAL OF ORGANIC CHEMISTRY, 2009, 74 (18) :6999-7006
[4]  
Kankala S, 2015, RSC ADV, V5
[5]  
Li Y, 2015, PROCEEDINGS OF 2015 IEEE INTERNATIONAL CONFERENCE ON GREY SYSTEMS AND INTELLIGENT SERVICES (GSIS), P97, DOI 10.1109/GSIS.2015.7301836
[6]   DBU-Catalyzed Three-Component One-Pot Synthesis of Highly Functionalized Pyridines in Aqueous Ethanol [J].
Mamgain, Ritu ;
Singh, Rain ;
Rawat, Diwan S. .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 46 (01) :69-73
[7]   Anti-inflammatory, analgesic and antipyretic 4,6-disubstituted 3-cyano-2-aminopyridines [J].
Manna, F ;
Chimenti, F ;
Bolasco, A ;
Bizzarri, B ;
Filippelli, W ;
Filippelli, A ;
Gagliardi, L .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1999, 34 (03) :245-254
[8]   Convenient, multicomponent, one-pot synthesis of highly substituted pyridines under solvent-free conditions [J].
Mobinikhaledi, Akbar ;
Asadbegi, Sajad ;
Bodaghifard, Mohammad Ali .
SYNTHETIC COMMUNICATIONS, 2016, 46 (19) :1605-1611
[9]   Green synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitriles using ZnO nanoparticles prepared with mulberry leaf extract and ZnCl2 [J].
Mobinikhaledi, Akbar ;
Yazdanipour, Atisa ;
Ghashang, Majid .
TURKISH JOURNAL OF CHEMISTRY, 2015, 39 (03) :667-675
[10]   Rapid and Efficient One-Pot Synthesis of 1,4-Dihydropyridine and Polyhydroquinoline Derivatives Through the Hantzsch Four Component Condensation by Zinc Oxide [J].
Moghaddam, F. Matloubi ;
Saeidian, H. ;
Mirjafary, Z. ;
Sadeghi, A. .
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2009, 6 (02) :317-324