Identification of organoselenium compounds that possess chemopreventive properties in human prostate cancer LNCaP cells

被引:42
作者
Terazawa, Riyako [1 ]
Garud, Dinesh R. [2 ]
Hamada, Nanako [1 ]
Fujita, Yasunori [1 ]
Itoh, Tomohiro [1 ]
Nozawa, Yoshinori [1 ,3 ]
Nakane, Keita [4 ]
Deguchi, Takashi [4 ]
Koketsu, Mamoru [5 ]
Ito, Masafumi [1 ]
机构
[1] Gifu Int Inst Biotechnol, Dept Longev & Aging Res, Gifu 5040838, Japan
[2] Gifu Univ, Dept Chem, Fac Engn, Gifu 5011193, Japan
[3] Tokai Gakuin Univ, Dept Food & Hlth, Gifu 5048511, Japan
[4] Gifu Univ, Grad Sch Med, Dept Urol, Gifu 5011193, Japan
[5] Gifu Univ, Dept Mat Sci & Technol, Fac Engn, Gifu 5011193, Japan
关键词
Organoselenium compound; Nrf2; Antioxidant response element; Heme oxygenase-1; Oxidative stress; Cell growth inhibition; Chemoprevention; Prostate cancer; ANTIOXIDANT-RESPONSIVE ELEMENT; DRUG-METABOLIZING-ENZYMES; HEME OXYGENASE-1; OXIDATIVE STRESS; PREVENTION TRIAL; NRF2; ACTIVATION; SERUM SELENIUM; VITAMIN-E; EBSELEN; RISK;
D O I
10.1016/j.bmc.2010.08.019
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The process of cancer development consists of three sequential stages termed initiation, promotion, and progression. Oxidative stress damages DNA and introduces mutations into oncogenes or tumor suppressor genes, thus contributing to cancer development. Cancer chemoprevention is defined to prevent or delay the development of cancer by the use of natural or synthetic substances. In the present study, we synthesized a series of organoselenium compounds and evaluated their possible chemopreventive properties in human prostate cancer LNCaP cells. Among 42 organoselenium compounds tested, two compounds, 3-selena-1-dethiacephem 13 and 3-selena-1-dethiacephem 14 strongly activated the Nrf2/ARE (antioxidant response element) signaling and thus markedly increased expression of heme oxygenase-1 (HO-1), a phase II antioxidant enzyme. Translocation of Nrf2 to the nucleus preceded HO-1 protein induction by two compounds. The intracellular ROS level was strongly reduced immediately after treatment with these compounds, showing that they are potent antioxidants. Finally, both compounds inhibited cell growth via cell cycle arrest. Our findings suggest that compounds 13 and 14 could not only attenuate oxidative stress through Nrf2/ARE activation and direct ROS scavenging but also inhibit cell growth. Thus, these compounds possess the potential as pharmacological agents for chemoprevention of human prostate cancer. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:7001 / 7008
页数:8
相关论文
共 50 条
[41]   Emodin induces apoptosis in human prostate cancer cell LNCaP [J].
Yu, Chun-Xiao ;
Zhang, Xiao-Qian ;
Kang, Lu-Dong ;
Zhang, Peng-Ju ;
Chen, Wei-Wen ;
Liu, Wen-Wen ;
Liu, Qing-Wei ;
Zhang, Jian-Ye .
ASIAN JOURNAL OF ANDROLOGY, 2008, 10 (04) :625-634
[42]   PrLZ Expression Is Associated With the Progression of Prostate Cancer LNCaP Cells [J].
Li, Lei ;
Zhang, Dong ;
Zhang, Linlin ;
Zhu, Guodong ;
Sun, Yi ;
Wu, Kaijie ;
Wang, Xinyang ;
He, Dalin .
MOLECULAR CARCINOGENESIS, 2009, 48 (05) :432-440
[43]   The Chemopreventive Effects of Carpesium abrotanoides Are Mediated by Induction of Phase II Detoxification Enzymes and Apoptosis in Human Colorectal Cancer Cells [J].
Lee, Saet Byoul ;
Kang, Kyungsu ;
Lee, Hee Ju ;
Yun, Ji Ho ;
Jho, Eun Hye ;
Kim, Chul Young ;
Nho, Chu Won .
JOURNAL OF MEDICINAL FOOD, 2010, 13 (01) :39-46
[44]   Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells [J].
Nair, Sujit ;
Li, Wenge ;
Kong, Ah-Ng Tony .
ACTA PHARMACOLOGICA SINICA, 2007, 28 (04) :459-472
[45]   Modulation of energetic and lipid pathways by curcumin as a potential chemopreventive strategy in human prostate cancer cells [J].
Pellegrino, Michele ;
Occhiuzzi, Maria Antonietta ;
Grande, Fedora ;
Pagani, Ilaria Stefania ;
Aquaro, Stefano ;
Tucci, Paola .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 735
[46]   α-Keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells [J].
Nian, Hui ;
Bisson, William H. ;
Dashwood, Wan-Mohaiza ;
Pinto, John T. ;
Dashwood, Roderick H. .
CARCINOGENESIS, 2009, 30 (08) :1416-1423
[47]   Heterocyclic Compounds Derivatives Inhibit Human Prostate Cancer Cells [J].
Yu, Wang-Hai ;
Song, Li-De ;
Zhu, Ling-Fei .
LATIN AMERICAN JOURNAL OF PHARMACY, 2018, 37 (06) :1120-1124
[48]   STEAP1 regulation and its influence modulating the response of LNCaP prostate cancer cells to bicalutamide, enzalutamide and apalutamide [J].
Rocha, Sandra M. ;
Nascimento, Daniel ;
Cardoso, Ana Margarida ;
Passarinha, Luis ;
Socorro, Silvia ;
Maia, Claudio J. .
MOLECULAR MEDICINE REPORTS, 2023, 27 (02)
[49]   Title Changes in the Mineral Composition of Rat Femoral Bones Induced by Implantation of LNCaP Prostate Cancer Cells and Dietary Supplementation [J].
Skrajnowska, Dorota ;
Jagielska, Agata ;
Ruszczynska, Anna ;
Wagner, Barbara ;
Bielecki, Wojciech ;
Bobrowska-Korczak, Barbara .
NUTRIENTS, 2021, 13 (01) :1-27
[50]   Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells [J].
Lee, Soo Ok ;
Pinder, Elaine ;
Chun, Jae Yeon ;
Lou, Wei ;
Sun, Meng ;
Gao, Allen C. .
PROSTATE, 2008, 68 (01) :85-91