Personalized risk assessment of heart failure patients: More perspectives from transforming growth factor super-family members

被引：14

作者：

Goletti, S. ^{[1
,2
]}

Gruson, D. ^{[1
,2
,3
]}

机构：

[1] Clin Univ St Luc, Dept Lab Med, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, B-1200 Brussels, Belgium

[3] Clin Univ St Luc, Inst Rech Expt & Clin, Pole Rech Endocrinol Diabet & Nutr, B-1200 Brussels, Belgium

来源：

CLINICA CHIMICA ACTA | 2015年 / 443卷

关键词：

Myostatin; Activin; GDF-15; GDF-11; Prognosis; Heart; DIFFERENTIATION FACTOR 15; ISCHEMIA-REPERFUSION INJURY; PRESERVED EJECTION FRACTION; EPICARDIAL ADIPOSE-TISSUE; TYPE-2; DIABETES-MELLITUS; BETA SUPERFAMILY MEMBER; ACTIVIN-A; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; CARDIAC-HYPERTROPHY;

D O I：

10.1016/j.cca.2014.09.014

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

More personalized risk assessment of patients with heart failure (HF) is important to develop more tailored based care and for a better allocation of resources. The measurement of biomarkers is now part of the standards of care and is important for the sub-phenotyping of HF patients to demonstrate the activation of pathophysiological pathways engaged in the worsening of HF. The sub-phenotyping of patients can lead therefore to a more personalized selection of the treatment. Several members of the transforming growth factor beta (TGF-beta) super-family, such as myostatin, activin A, GDF-15 and GDF-11, are involved in cardiac remodeling and the evaluation of their circulating levels might provide new insights to the course of the disease and also to guide prognostication and therapeutic selection of HF patients. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：94 / 99

页数：6

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