Impact of Helicobacter pylori infection on gut microbiota

被引:35
作者
Iino, Chikara [1 ]
Shimoyama, Tadashi [1 ,2 ]
机构
[1] Hirosaki Univ, Grad Sch Med, Dept Gastroenterol, Hirosaki, Aomori 0368562, Japan
[2] Aomori Gen Hlth Examinat Ctr, Dept Internal Med, 2-19-12 Tsukuda, Aomori 0300962, Japan
关键词
Helicobacter pylori; Gut microbiota; Atrophic gastritis; Eradication; Proton pump inhibitor; ERADICATION; ACID; CAGA;
D O I
10.3748/wjg.v27.i37.6224
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A number of studies have revealed the association between Helicobacter pylori (H. pylori) infection and the gut microbiota. More than half of the investigations on the impact of H. pylori on the gut microbiota have been the sub-analyses of the influence of eradication therapy. It was observed that H. pylori eradication altered gut microbiota within a short period after eradication, and majority of the alterations took a long period of time to reverse back to the original. Changes in the gut microbiota within a short period after eradication may be attributed to antibiotics and proton pump inhibitors. Modification of gastric acidity in the stomach caused by a long-term H. pylori infection alters the gut microbiota. Analysis of the gut microbiota should be conducted in a large population, adjusting for considerable biases associated with the composition of the gut microbiota, such as age, sex, body mass index, diet and the virulence of H. pylori.
引用
收藏
页码:6224 / 6230
页数:7
相关论文
共 41 条
[1]   Gastrointestinal Malignancy and the Microbiome [J].
Abreu, Maria T. ;
Peek, Richard M., Jr. .
GASTROENTEROLOGY, 2014, 146 (06) :1534-U166
[2]   Body Mass Index and Sex Affect Diverse Microbial Niches within the Gut [J].
Borgo, Francesca ;
Garbossa, Stefania ;
Riva, Alessandra ;
Severgnini, Marco ;
Luigiano, Carmelo ;
Benetti, Albero ;
Pontiroli, Antonio E. ;
Morace, Giulia ;
Borghi, Elisa .
FRONTIERS IN MICROBIOLOGY, 2018, 9
[3]   Influence of anti-Helicobacter triple-therapy with metronidazole, omeprazole and clarithromycin on intestinal microflora [J].
Bühling, A ;
Radun, D ;
Müller, WA ;
Malfertheiner, P .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2001, 15 (09) :1445-1452
[4]   The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial [J].
Chen, Luyi ;
Xu, Wenli ;
Lee, Allen ;
He, Jiamin ;
Huang, Bixia ;
Zheng, Wenfang ;
Su, Tingting ;
Lai, Sanchuan ;
Long, Yanqin ;
Chu, Hua ;
Chen, Yujia ;
Wang, Lan ;
Wang, Kan ;
Si, Jianmin ;
Chen, Shujie .
EBIOMEDICINE, 2018, 35 :87-96
[5]   Exploring the impact of Helicobacter pylori on gut microbiome composition [J].
Dash, Nihar Ranjan ;
Khoder, Ghalia ;
Nada, Aml Mohamed ;
Al Bataineh, Mohammad Tahseen .
PLOS ONE, 2019, 14 (06)
[6]   Helicobacter pylori infection associates with fecal microbiota composition and diversity [J].
Frost, Fabian ;
Kacprowski, Tim ;
Ruehlemann, Malte ;
Bang, Corinna ;
Franke, Andre ;
Zimmermann, Kathrin ;
Nauck, Matthias ;
Voelker, Uwe ;
Voelzke, Henry ;
Biffar, Reiner ;
Schulz, Christian ;
Mayerle, Julia ;
Weiss, Frank U. ;
Homuth, Georg ;
Lerch, Markus M. .
SCIENTIFIC REPORTS, 2019, 9 (1)
[7]   Intestinal microbiota in human health and disease: the impact of probiotics [J].
Gerritsen, Jacoline ;
Smidt, Hauke ;
Rijkers, Ger T. ;
de Vos, Willem M. .
GENES AND NUTRITION, 2011, 6 (03) :209-240
[8]   Lack of significant differences between gastrointestinal tract microbial population structure ofHelicobacter pylori-infected subjects before and 2 years after a single eradication event [J].
Gudra, Dita ;
Pupola, Darta ;
Skenders, Girts ;
Leja, Marcis ;
Radovica-Spalvina, Ilze ;
Gorskis, Henrihs ;
Vangravs, Reinis ;
Fridmanis, Davids .
HELICOBACTER, 2020, 25 (05)
[9]   Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer [J].
Guo, Yang ;
Zhang, Yang ;
Gerhard, Markus ;
Gao, Juan-Juan ;
Mejias-Luque, Raquel ;
Zhang, Lian ;
Vieth, Michael ;
Ma, Jun-Ling ;
Bajbouj, Monther ;
Suchanek, Stepan ;
Liu, Wei-Dong ;
Ulm, Kurt ;
Quante, Michael ;
Li, Zhe-Xuan ;
Zhou, Tong ;
Schmid, Roland ;
Classen, Meinhard ;
Li, Wen-Qing ;
You, Wei-Cheng ;
Pan, Kai-Feng .
GUT, 2020, 69 (09) :1598-1607
[10]  
Haruma K, 1999, ALIMENT PHARM THERAP, V13, P155