Bortezomib in combination with infusional dose-adjusted EPOCH for the treatment of plasmablastic lymphoma

被引：59

作者：

Castillo, Jorge J. ^{[1
]}

Reagan, John L. ^{[2
]}

Sikov, William M. ^{[3
]}

Winer, Eric S. ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02215 USA

[2] Brown Univ, Miriam Hosp, Warren Alpert Med Sch, Div Hematol & Oncol, Providence, RI USA

[3] Brown Univ, Women & Infants Hosp, Warren Alpert Med Sch, Program Womens Oncol, Providence, RI USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2015年 / 169卷 / 03期

关键词：

Plasmablastic lymphoma; bortezomib; EPOCH; B-CELL LYMPHOMA; CHEMOTHERAPY; RITUXIMAB; EFFICACY;

D O I：

10.1111/bjh.13300

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasmablastic lymphoma (PBL) is a rare and aggressive CD20-negative lymphoma. Despite improvements of the biology behind PBL, it still represents a challenge from the diagnostic and therapeutic perspectives for pathologists and clinicians. PBL is characterized by high rates of relapse and short median survival with standard approaches. Here, we report the use of the combination of bortezomib and infusional etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (V-EPOCH) in three patients with PBL; two were HIV-positive and one was HIV-negative. All three patients obtained a durable complete response to V-EPOCH with survival times of 24, 18 and 12months respectively.

引用

页码：352 / 355

页数：4

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