Two new diterpene alkaloids from the South China Sea Sponge Agelas aff. nemoechinata

被引：14

作者：

Li, Tao ^{[1
]}

Wang, Bin ^{[2
]}

de Voogd, Nicole J. ^{[3
]}

Tang, Xu-Li ^{[4
]}

Wang, Qi ^{[5
]}

Chu, Mei-Jun ^{[5
]}

Li, Ping-Lin ^{[5
]}

Li, Guo-Qiang ^{[5
]}

机构：

[1] Zhejiang Ocean Univ, Marine Sci & Technol Coll, Zhoushan 316022, Peoples R China

[2] Zhejiang Ocean Univ, Sch Food & Pharm, Zhoushan 316022, Peoples R China

[3] Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands

[4] Ocean Univ China, Coll Chem & Chem Engn, Qingdao 266100, Peoples R China

[5] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2016年 / 27卷 / 07期

基金：

中国国家自然科学基金;

关键词：

South China Sea; Marine sponge; Agelas; Diterpene alkaloids; Cytotoxic; ANTIMICROBIAL METABOLITES; UNIT;

D O I：

10.1016/j.cclet.2016.05.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new N-methyladenine-containing diterpenes, nemoechines F (1) and G (2), were isolated from the South China Sea sponge Agelas aff. nemoechinata. The structures were assigned on the basis of spectroscopic date. Compound 2 showed weak activity against Jurkat cell lines with IC50 of 17.1 mu mol/L. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1048 / 1051

页数：4

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