Cysteine metabolism-related genes and bacterial resistance to potassium tellurite

被引：44

作者：

Fuentes, Derie E. ^{[3
]}

Fuentes, Eugenia L. ^{[3
]}

Castro, Miguel E. ^{[3
]}

Perez, Jose M. ^{[3
]}

Araya, Manuel A. ^{[3
]}

Chasteen, Thomas G. ^{[2
]}

Pichuantes, Sergio E. ^{[1
]}

Vasquez, Claudio C. ^{[3
]}

机构：

[1] Novartis Vaccines & Diagnost Inc, Emeryville, CA USA

[2] Sam Houston State Univ, Dept Chem, Huntsville, TX 77340 USA

[3] Univ Santiago Chile, Fac Quim & Biol, Dept Ciencias Biol, Santiago, Chile

来源：

JOURNAL OF BACTERIOLOGY | 2007年 / 189卷 / 24期

关键词：

D O I：

10.1128/JB.01252-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cobA, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium.

引用

页码：8953 / 8960

页数：8

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