Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

被引：40
作者：
Hong, H
Gates, PJ
Staunton, J
Stinear, T
Cole, ST
Leadlay, PF
Spencer, JB
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England
[3] Inst Pasteur, Unite Genet Mol Bacterienne, F-75015 Paris, France
来源：
CHEMICAL COMMUNICATIONS | 2003年 / 22期
关键词：
D O I：
10.1039/b308163j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
LC-MSn analysis of mycolactone toxin from extracts of Mycobacterium ulcerans has shown that minor co-metabolites, including two previously unreported, differ structurally from mycolactone only in a small portion of the polyketide side-chain.
引用
收藏
页码：2822 / 2823
页数：2
相关论文
共 9 条
  • [1] Stereochemistry of the core structure of the mycolactones
    Benowitz, AB
    Fidanze, S
    Small, PLC
    Kishi, Y
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (21) : 5128 - 5129
  • [2] Suspension cultivation of Mycobacterium ulcerans for the production of mycolactones
    Cadapan, LD
    Arslanian, RL
    Carney, JR
    Zavala, SM
    Small, PL
    Licari, P
    [J]. FEMS MICROBIOLOGY LETTERS, 2001, 205 (02) : 385 - 389
  • [3] Complete structure of the mycolactones
    Fidanze, S
    Song, FB
    Szlosek-Pinaud, M
    Small, PLC
    Kishi, Y
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (41) : 10117 - 10118
  • [4] Mycolactone:: A polyketide toxin from Mycobacterium ulcerans required for virulence
    George, KM
    Chatterjee, D
    Gunawardana, G
    Welty, D
    Hayman, J
    Lee, R
    Small, PLC
    [J]. SCIENCE, 1999, 283 (5403) : 854 - 857
  • [5] A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells
    George, KM
    Pascopella, L
    Welty, DM
    Small, PLC
    [J]. INFECTION AND IMMUNITY, 2000, 68 (02) : 877 - 883
  • [6] Characterization of novel macrolide toxins, mycolactones A and B, from a human pathogen, Mycobacterium ulcerans
    Gunawardana, G
    Chatterjee, D
    George, KM
    Brennan, P
    Whittern, D
    Small, PLC
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (25) : 6092 - 6093
  • [7] Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans:: Implications for virulence
    Mve-Obiang, A
    Lee, RE
    Portaels, F
    Small, PLC
    [J]. INFECTION AND IMMUNITY, 2003, 71 (02) : 774 - 783
  • [8] Rohr J, 2000, ANGEW CHEM INT EDIT, V39, P2847, DOI 10.1002/1521-3773(20000818)39:16<2847::AID-ANIE2847>3.0.CO
  • [9] 2-0
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