Nano-Drug Design Based on the Physiological Properties of Glutathione

被引：19
作者：
Li, Wenhua [1 ]
Li, Minghui [1 ]
Qi, Jing [1 ]
机构：
[1] Harbin Med Univ, Daqing Campus,39 Xinyang Rd, Harbin 163319, Peoples R China
来源：
MOLECULES | 2021年 / 26卷 / 18期
基金：
中国国家自然科学基金;
关键词：
glutathione; physiological property; nano-drugs; review; FLUORESCENT-PROBE; OXIDATIVE STRESS; INTRACELLULAR DRUG; WORMLIKE MICELLES; BLOCK-COPOLYMERS; REDOX; NANOPARTICLES; DELIVERY; PRODRUG; NANOCARRIERS;
D O I：
10.3390/molecules26185567
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glutathione (GSH) is involved in and regulates important physiological functions of the body as an essential antioxidant. GSH plays an important role in anti-oxidation, detoxification, anti-aging, enhancing immunity and anti-tumor activity. Herein, based on the physiological properties of GSH in different diseases, mainly including the strong reducibility of GSH, high GSH content in tumor cells, and the NADPH depletion when GSSH is reduced to GSH, we extensively report the design principles, effect, and potential problems of various nano-drugs in diabetes, cancer, nervous system diseases, fluorescent probes, imaging, and food. These studies make full use of the physiological and pathological value of GSH and develop excellent design methods of nano-drugs related to GSH, which shows important scientific significance and prominent application value for the related diseases research that GSH participates in or responds to.
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页数：19
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共 118 条
[31]   Redox-responsive polymers for drug delivery: from molecular design to applications [J].
Huo, Meng ;
Yuan, Jinying ;
Tao, Lei ;
Wei, Yen .
POLYMER CHEMISTRY, 2014, 5 (05) :1519-1528
[32]   A single benzene fluorescent probe for efficient formaldehyde sensing in living cells using glutathione as an amplifier [J].
Jana, Anal ;
Joseph, Manu M. ;
Munan, Subrata ;
Shamna, K. ;
Maiti, Kaustabh Kumar ;
Samanta, Animesh .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2021, 214
[33]   Curcumin Potentiates α7 Nicotinic Acetylcholine Receptors and Alleviates Autistic-Like Social Deficits and Brain Oxidative Stress Status in Mice [J].
Jayaprakash, Petrilla ;
Isaev, Dmytro ;
Shabbir, Waheed ;
Lorke, Dietrich E. ;
Sadek, Bassem ;
Oz, Murat .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)
[34]   Responsive, switchable wormlike micelles for CO2/N2 and redox dual stimuli based on selenium-containing surfactants [J].
Jiang, Jianzhong ;
Zhang, Duyan ;
Yin, JinChao ;
Cui, Zhenggang .
SOFT MATTER, 2017, 13 (37) :6458-6464
[35]   Disulfide-containing Macromolecules for Therapeutic Delivery [J].
Jiang, Ziwen ;
Thayumanavan, S. .
ISRAEL JOURNAL OF CHEMISTRY, 2020, 60 (1-2) :132-139
[36]   Recent progress in luminescent and colorimetric chemosensors for detection of thiols [J].
Jung, Hyo Sung ;
Chen, Xiaoqiang ;
Kim, Jong Seung ;
Yoon, Juyoung .
CHEMICAL SOCIETY REVIEWS, 2013, 42 (14) :6019-6031
[37]   Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review [J].
Kanamala, Manju ;
Wilson, William R. ;
Yang, Mimi ;
Palmer, Brian D. ;
Wu, Zimei .
BIOMATERIALS, 2016, 85 :152-167
[38]   Intracellular Drug Delivery Nanocarriers of Glutathione-Responsive Degradable Block Copolymers Having Pendant Disulfide Linkages [J].
Khorsand, Behnoush ;
Lapointe, Gabriel ;
Brett, Christopher ;
Oh, Jung Kwon .
BIOMACROMOLECULES, 2013, 14 (06) :2103-2111
[39]   Covalent binding of glutathione on magnetic nanoparticles: Application for immobilizing small fragment ubiquitin-like-specific protease 1 [J].
Kuan, Wei-Chih ;
Lai, Jian-Wen ;
Lee, Wen-Chien .
ENZYME AND MICROBIAL TECHNOLOGY, 2021, 143
[40]   Stimuli-responsive liposomes for drug delivery [J].
Lee, Y. ;
Thompson, D. H. .
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2017, 9 (05)
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