Cannabidiol Attenuates MK-801-Induced Cognitive Symptoms of Schizophrenia in the Passive Avoidance Test in Mice

被引:22
|
作者
Kruk-Slomka, Marta [1 ]
Biala, Grazyna [1 ]
机构
[1] Med Univ Lublin, Dept Pharmacol & Pharmacodynam, 4a Chodzki Str, PL-20093 Lublin, Poland
来源
MOLECULES | 2021年 / 26卷 / 19期
关键词
schizophrenia; cognitive disorders; memory and learning; cannabidiol; mice; passive avoidance test; SOCIAL-INTERACTION; WORKING-MEMORY; ANIMAL-MODEL; FEAR MEMORY; CB1; PHARMACOLOGY; RECOGNITION; INHIBITION; IMPAIRMENT; DEFICITS;
D O I
10.3390/molecules26195977
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Schizophrenia is a chronic mental disorder that disturbs feelings and behavior. The symptoms of schizophrenia fall into three categories: positive, negative, and cognitive. Cognitive symptoms are characterized by memory loss or attentional deficits, and are especially difficult to treat. Thus, there is intense research into the development of new treatments for schizophrenia-related responses. One of the possible strategies is connected with cannabidiol (CBD), a cannabinoid compound. This research focuses on the role of CBD in different stages of memory (acquisition, consolidation, retrieval) connected with fear conditioning in the passive avoidance (PA) learning task in mice, as well as in the memory impairment typical of cognitive symptoms of schizophrenia. Memory impairment was provoked by an acute injection of the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (animal model of schizophrenia). Our results revealed that an acute injection of CBD (30 mg/kg; intraperitoneally (i.p.) improved all phases of long-term fear memory in the PA test in mice. Moreover, the acute injection of non-effective doses of CBD (1 or 5 mg/kg; i.p.) attenuated the memory impairment provoked by MK-801 (0.6 mg/kg; i.p.) in the consolidation and retrieval stages of fear memory, but not in the acquisition of memory. The present findings confirm that CBD has a positive influence on memory and learning processes in mice, and reveals that this cannabinoid compound is able to attenuate memory impairment connected with hypofunction of glutamate transmission in a murine model of schizophrenia.
引用
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页数:19
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