Diversity-oriented functionalization of indolizines at the C3 position via multicomponent Kabachnik-Fields reaction

被引：11
作者：
Kim, Jinwoo
Heo, Yunkyung
Jung, Youngeun
Lee, Jinu [1 ]
Kim, Ikyon [1 ]
机构：
[1] Yonsei Univ, Coll Pharm, 85 Songdogwahak Ro, Incheon 21983, South Korea
来源：
TETRAHEDRON | 2017年 / 73卷 / 39期
基金：
新加坡国家研究基金会;
关键词：
Multicomponent reaction; Aminophosphonates; Indolizine; Diversity-oriented synthesis; Gap junction inhibition; JUNCTIONAL INTERCELLULAR COMMUNICATION; ONE-POT SYNTHESIS; ALPHA-AMINOPHOSPHONATES; AMINO-ACIDS; EFFICIENT; PHOSPHONATES; COMPLEXITY; INHIBITORS; BIOLOGY; ROUTE;
D O I：
10.1016/j.tet.2017.08.017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A diversity-oriented approach to new indolizines highly functionalized at the C3 position was achieved by using the Kabachnik-Fields three-component reaction. Some of the synthesized compounds exhibited a significant gap junction inhibitory activity. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5759 / 5768
页数：10
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