A Critical Analysis of Bio-Hydrocarbon Production in Bacteria: Current Challenges and Future Directions

被引：10

作者：

Rahman, Ziaur ^{[1
]}

Nawab, Javed ^{[2
]}

Sung, Bong Hyun ^{[3
]}

Kim, Sun Chang ^{[4
]}

机构：

[1] Abdul Wali Khan Univ Mardan, Dept Microbiol, Mardan 23200, Pakistan

[2] Abdul Wali Khan Univ Mardan, Dept Environm Sci, Mardan 23200, Pakistan

[3] Korea Res Inst Biosci & Biotechnol, Cell Factory Res Ctr, Daejeon 34141, South Korea

[4] Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon 34141, South Korea

来源：

ENERGIES | 2018年 / 11卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

microbial biofuel; metabolic engineering; alkanes; alcohols; RIBOSOME RECYCLING FACTOR; ESCHERICHIA-COLI; SYNTHETIC BIOLOGY; SACCHAROMYCES-CEREVISIAE; YARROWIA-LIPOLYTICA; FATTY-ACID; CI ENGINES; ENERGY; BIOFUELS; PATHWAY;

D O I：

10.3390/en11102663

中图分类号：

TE [石油、天然气工业]; TK [能源与动力工程];

学科分类号：

0807 ; 0820 ;

摘要：

As global fossil reserves are abruptly diminishing, there is a great need for bioenergy. Renewable and sustainable bioenergy products such as biofuels could fulfill the global energy demand, while minimizing global warming. Next-generation biofuels produced by engineered microorganisms are economical and do not rely on edible resources. The ideal biofuels are alcohols and n-alkanes, as they mimic the molecules in fossil fuels and possess high energy densities. Alcohols and n-alkane hydrocarbons (C-2 to C-18) have been produced using engineered microorganisms. However, it is difficult to optimize the complex metabolic networks in engineered microorganisms to obtain these valuable bio-hydrocarbons in high yields. Metabolic engineering results in drastic and adverse cellular changes that minimize production yield in microbes. Here, we provide an overview of the progress in next-generation biofuel (alcohols and n-alkanes) production in various engineered microorganisms and discuss the latest tools for strain development that improve biofuel production.

引用

页数：14