Reduced dynamics of functional connectivity and cognitive impairment in multiple sclerosis

被引：46

作者：

D'Ambrosio, Alessandro ^{[1
]}

Valsasina, Paola ^{[1
]}

Gallo, Antonio ^{[2
]}

De Stefano, Nicola ^{[3
]}

Pareto, Deborah ^{[4
]}

Barkhof, Frederik ^{[5
,6
]}

Ciccarelli, Olga ^{[6
]}

Enzinger, Christian ^{[7
]}

Tedeschi, Gioacchino ^{[2
]}

Stromillo, M. Laura ^{[3
]}

Arevalo, Maria J. ^{[8
]}

Hulst, Hanneke E. ^{[9
]}

Muhlert, Nils ^{[6
]}

Koini, Marisa ^{[7
]}

Filippi, Massimo ^{[1
,10
]}

Rocca, Maria A. ^{[1
,10
]}

机构：

[1] Univ Vita Salute San Raffaele, Inst Expt Neurol, San Raffaele Sci Inst, Div Neurosci,Neuroimaging Res Unit, Via Olgettina 60, I-20132 Milan, Italy

[2] Univ Campania L Vanvitelli, Dept Med Surg Neurol Metab & Aging Sci, Div Neurol 1, Naples, Italy

[3] Univ Siena, Dept Med Surg & Neurosci, Siena, Italy

[4] Hosp Univ Vall dHebron, Dept Radiol, Magnet Resonance Unit, Barcelona, Spain

[5] Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[6] UCL, UCL Inst Neurol, Dept Neuroinflammat, Queen Sq MS Ctr, London, England

[7] Med Univ Graz, Dept Neurol, Graz, Austria

[8] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Multiple Sclerosis Ctr Catalonia Cemcat, Dept Neurol Neuroimmunol, Barcelona, Spain

[9] Vrije Univ Amsterdam Med Ctr, MS Ctr Amsterdam, Dept Anat & Neurosci, Amsterdam Neurosci, Amsterdam, Netherlands

[10] Univ Vita Salute San Raffaele, Dept Neurol, Inst Expt Neurol, Div Neurosci,San Raffaele Sci Inst, Milan, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2020年 / 26卷 / 04期

关键词：

Cognitive impairment; functional connectivity; functional magnetic resonance imaging; multiple sclerosis; resting state; brain dynamics; DEFAULT-MODE NETWORK; BRAIN CONNECTIVITY; DYSFUNCTION; FREQUENCY; SEVERITY; RELEVANT;

D O I：

10.1177/1352458519837707

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: In multiple sclerosis (MS), abnormalities of brain network dynamics and their relevance for cognitive impairment have never been investigated. Objectives: The aim of this study was to assess the dynamic resting state (RS) functional connectivity (FC) on 62 relapsing-remitting MS patients and 65 sex-matched healthy controls enrolled at 7 European sites. Methods: MS patients underwent clinical and cognitive evaluation. Between-group network FC differences were evaluated using a dynamic approach (based on sliding-window correlation analysis) and grouping correlation matrices into recurrent FC states. Results: Dynamic FC analysis revealed, in healthy controls and MS patients, three recurrent FC states: two characterized by strong intra- and inter-network connectivity and one characterized by weak inter-network connectivity (State 3). A total of 23 MS patients were cognitively impaired (CI). Compared to cognitively preserved (CP), CI-MS patients had reduced RS-FC between subcortical and default-mode networks in the low-connectivity State 3 and lower dwell time (i.e. time spent in a given state) in the high-connectivity State 2. CI-MS patients also exhibited a lower number and a less frequent switching between meta-states, as well as a smaller distance traveled through connectivity states. Conclusion: Time-varying RS-FC was markedly less dynamic in CI- versus CP-MS patients, suggesting that slow inter-network connectivity contributes to cognitive dysfunction in MS.

引用

页码：476 / 488

页数：13

共 35 条

[21] Higher Dimensional Meta-State Analysis Reveals Reduced Resting fMRI Connectivity Dynamism in Schizophrenia Patients [J].